This page tracks new and upcoming treatment options for tinnitus. What’s in development? What’s promising? What’s available soon? Current topics include FX-322, OTO-313, Susan Shore device, GW-201, tetrandrine, Jianxin Bao, Lenire, NAC/HPN-07, CS0022 (BMS-191011), RCOR1, RL-81, and more. Jump to section: News, Research, Clinical Trials
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News
- Frequency Therapeutics Announces Publication of Phase 1/2 Data Showing Hearing Improvements in Patients Receiving FX-322 Feb 22, 2021
- Novel Tinnitus Drug CS0022 Reduces Chronic Tinnitus in Preclinical Study Feb 8, 2021
- Discovery of a New Type of Inhibitory Neuron [L-stellate cells] Holds Clues About Tinnitus Feb 4, 2021
- BREAKTHROUGH: NAC/HPN-07, also known as the Hough Ear Institute’s NHPN-1010, significantly reduced the incidence of tinnitus, study finds… Jan 7, 2021
- American Tinnitus Association Receives $2.7 Million Donation – Money Will Help Fund Strategic Long-Term Tinnitus Research Dec 26, 2020
- Hubert Lim on Neuromodulation and Research Behind the Lenire Device for Tinnitus [PDF] Dec 14, 2020
- What can biobanks bring to hearing, and in particular to tinnitus? Dec 4, 2020
- British Tinnitus Association awards £125k grant for research that could predict who will develop tinnitus Dec 4, 2020
- Otonomy expects to start Phase 2 trial of OTO-313 in tinnitus in first quarter of 2021 Nov 30, 2020
- In Case You Missed It: Tinnitus Hub Director Hazel Goedhart gives us the cold, hard, unbiased facts about Lenire… Nov 24, 2020
- Researchers Develop New Technology to Objectively Measure Tinnitus Nov 19, 2020
- Technology lets clinicians objectively detect tinnitus for first time Nov 18, 2020
- New FX-322 clinical trial for severe hearing loss includes tinnitus assessment as secondary outcome measure Nov 16, 2020
- The role of prediction and gain in tinnitus Nov 2, 2020
- Frequency Therapeutics Will Report FX-322 Phase 2a Study Data in Late Q1 2021 Oct 29, 2020
- Neuromod Successfully Closes $12.4 Million Series B Financing for Tinnitus Treatment Device Lenire® Oct 20, 2020
- Auckland University researchers trialing MDMA as tinnitus cure Oct 17, 2020
- Heavy metals could play important role in development of tinnitus, study finds Oct 12, 2020
- New Tinnitus Treatment Alleviates Annoying Ringing in the Ears: A noninvasive device [Lenire] designed to rewire brain circuits reduced symptoms of tinnitus in a large, exploratory clinical trial Oct 7, 2020
- Is tinnitus all in the genes? Sep 25, 2020
- How much will FX-322 cost? David Lucchino, Frequency Therapeutics CEO, responds… Sep 24, 2020
- Frequency Therapeutics Completes Enrollment of FX-322 Phase 2a Study for Sensorineural Hearing Loss Sep 22, 2020
- Proposed “Multi-Cause Framework” of Tinnitus May Speed Up Development of New Therapies Sep 17, 2020
- Possible tinnitus gene found: Genetic variation in RCOR1 is associated with tinnitus Sep 14, 2020
- Frequency Therapeutics Presents Results Demonstrating Sustained Improvement in Hearing Loss Patients Treated with FX-322 Sep 13, 2020
- First report showing benefit of spinal cord stimulation in tinnitus Sep 12, 2020
- Dr. Will Sedley discusses role of “predictive brain processing” in tinnitus – via Tinnitus Talk [PDF] Sep 7, 2020
- British Tinnitus Association’s 2020 Tinnitus Conference Goes Virtual: October 5 – 9 Aug 27, 2020
- Not-yet-published tinnitus research preprints… Aug 26, 2020
- FX-322 phase 2a study results anticipated in second quarter of 2021… Aug 12, 2020
- Carl LeBel (Chief Development Officer at Frequency Therapeutics) talks FX-322 in latest interview – via Tinnitus Talk [PDF] Jul 25, 2020
- Update on new tinnitus drug (GW-201) from NEOMED researcher Jianxin Bao and Gateway Biotechnology Jul 20, 2020
- NEOMED researcher receives federal grant for first human tinnitus treatment Jul 15, 2020
- NIH Funds NEOMED Tinnitus Researcher Jul 8, 2020
- Otonomy Reports Positive Top-Line Results from Phase 1/2 Clinical Trial of OTO-313 in Patients with Tinnitus Jul 6, 2020
- Otonomy Provides Update on Clinical Trials: Results from Phase 1/2 trial of OTO-313 for tinnitus expected in July 2020 Jun 15, 2020
- Congressman Announces National Institute on Deafness and Other Communications Disorders Grant for Tinnitus Prevention and Treatment Jun 11, 2020
- Frequency Therapeutics Shares Clinical Data From Exploratory Study Confirming Delivery of FX-322 to the Cochlea – Top-Line Results Show Consistent Drug Entry in All Patients May 14, 2020
- FAU researchers use computer-based ‘stochastic resonance’ model of tinnitus as a basis for developing new treatment strategies May 13, 2020
- Updated list of hearing loss treatment news and research available at HearingLossTreatmentReport.com May 1, 2020
- Tinnitus Research Spotlight: A unified explanation of tinnitus development based on the Stochastic Resonance (SR) model of auditory perception Apr 21, 2020
- NO COVID-19 SLOWDOWN: Frequency Therapeutics Adds Another Recruitment Site for FX-322 Phase 2a Study (HearingLossTreatmentReport.com) Apr 14, 2020
- Treatments for tinnitus may need to enhance cortical plasticity rather than reverse it… Mar 24, 2020
- Study findings demonstrate that Lenire (Neuromod) for tinnitus “provides safe, fast-acting (within 6 weeks) and reproducible therapeutic effects that can last at least 12 months.” Mar 11, 2020
- Toward Tinnitus Subtyping: or Finding a Specific Personalized Treatment for Each Patient Feb 15, 2020
- Why Tinnitus Needs Citizen Science: A Researcher’s Perspective Feb 8, 2020
- Developing effective treatments or even a cure for tinnitus Feb 3, 2020
- Resaphene Suisse AG: Charité Ethics Committee in Berlin Approves Study on Tinniwell Tinnitus Therapy Jan 21, 2020
- Cognosetta, Inc receives funding from NIH to test a novel therapeutic for treating tinnitus (BMS-191011) Jan 14, 2020
- New ‘fast-track’ system for tinnitus and hearing loss Jan 10, 2020
- Auris Medical Receives “Intention to Grant” notice from European Patent Office for New Oral NKCC1 inhibitor Treatment for Tinnitus Jan 10, 2020
- Zilentin: Auris Medical Announces Formation of New Subsidiary for Development Projects in Tinnitus and Hearing Loss Dec 30, 2019
- American Tinnitus Association and British Tinnitus Association Partner to Spark Innovations in Tinnitus Treatments and Advance Global Discussion About Potential Tinnitus Breakthroughs Dec 10, 2019
- Proof of concept to support MDMA as a potential treatment for tinnitus? Dec 10, 2019
- Frequency Therapeutics CEO: “We have opened all U.S. sites for our Phase 2a study of FX-322 and remain on track to report top-line data in the second half of next year.” Nov 18, 2019
- RESEARCH: Experimental procedure enables suppression of auditory cortex alpha activity in patients with chronic tinnitus Nov 17, 2019
- Neuromodulation for Tinnitus Relief: Interview with Neuromod Devices CEO Dr. Ross O’Neill Oct 24, 2019
- The cortisol awakening response: could this be an effective measure of tinnitus distress? Oct 23, 2019
- FDA Grants FX-322 Fast Track Designation Oct 10, 2019
- Frequency Therapeutics Begins Recruiting for Phase 2 Study of FX-322 in Patients with Sensorineural Hearing Loss Oct 9, 2019
- VIDEO: Susan Shore on Bimodal Stimulation for Tinnitus – #TRI2019 (via TinnitusHub) Oct 8, 2019
- Neuromod (Lenire) Clinical Trial Data “Locked” Until Fall 2020? Study Results “Delayed” Until 2021? Oct 3, 2019
- Neuromod Successfully Closes €8 Million Capital Raise: proceeds will be used to accelerate ongoing commercialization of Lenire® tinnitus treatment device Sep 26, 2019
- A Breakthrough in Understanding Tinnitus: The Entire Hearing System Studied Sep 25, 2019
- Possible Link Between Marijuana Use, Tinnitus Sep 16, 2019
- Auris Medical Receives FDA and EMA Guidance for Keyzilen® (AM-101) Late-Stage Clinical Development Program Sep 13, 2019
- ABSTRACT: Phase 1/2 Hearing Loss Trial of Intratympanic FX322, a Progenitor Cell Activator Sep 11, 2019
- BREAKING: FX-322 Clinical Trial Results… Sep 6, 2019
- Auris Medical Announces Formation of Scientific Advisory Board for Tinnitus Programs Aug 26, 2019
- UA Rodent Study Identifies Possible Tinnitus Treatment Target Aug 26, 2019
- Brain Inflammation Identified as Potential Target to Treat Tinnitus Aug 20, 2019
- Tinnitus Cure Map from the British Tinnitus Association [image] Aug 6, 2019
- Frequency Therapeutics prepares to advance first-in-class drug candidate FX-322 into Phase 2a study… Jul 23, 2019
- Otonomy Expands Recruiting Locations for Phase 1/2 Clinical Trial of OTO-313 in Patients with Subjective Tinnitus Jul 20, 2019
- The Truth About Tinnitus Habituation: Deficient Sensory Gating Could Explain Why Many Tinnitus Victims Do Not Habituate Jul 18, 2019
- Frequency Therapeutics licenses FX-322 outside U.S. to Astellas Pharma for $80M. Both companies will work on global clinical trials for the treatment and coordinate launch efforts. Jul 17, 2019
- New Treatment-Related Research from Dr. Susan Shore: Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies Jul 14, 2019
- Research Roundup: 20+ field reports from the Tinnitus Research Initiative (TRI) 2019 Conference in Taipei Jul 2, 2019
- New findings support the view that tinnitus could be a proprioceptive illusion related to the middle-ear muscles Jun 27, 2019
- Susan Shore: Cochlear damage may be necessary but not sufficient to induce tinnitus Jun 26, 2019
- Drug to reduce brain inflammation cured tinnitus in mice – paving the way towards a pill for humans Jun 18, 2019
- Reducing brain inflammation could treat tinnitus and other hearing loss-related disorders Jun 18, 2019
- New breakthrough pill could cure tinnitus [sensationalized headline] Jun 18, 2019
- Sound Pharmaceuticals Completes Phase 2 Study of SPI-1005 for the Treatment of Tinnitus and Vertigo in Patients with Meniere’s Disease Jun 18, 2019
- UPDATE: Frequency Therapeutics to present newest FX-322 clinical trial results on September 17, 2019 [early] Jun 6, 2019
- What’s really going on in the world of tinnitus research? Seven insights from the #TRI2019 Conference… May 31, 2019
- New study results raise serious concerns about effectiveness of Tinnitus Retraining Therapy (TRT) May 25, 2019
- Frequency Therapeutics to present major FX-322 update on September 18, 2019 at AAO-HNSF Annual Meeting in New Orleans May 18, 2019
- Possible tinnitus remedy uncovered during ethnobotanical study of medicinal plants used in Central Macedonia, Greece May 14, 2019
- Major analysis of tinnitus patients’ hearing loss points to “stochastic resonance” (SR) as root cause of tinnitus May 14, 2019
- Neuromod Broadens Senior Leadership Team in Preparation for Global Commercialisation of Lenire™ Tinnitus Treatment May 8, 2019
- Neuromod updates anticipated study completion date of device clinical trial May 8, 2019
- First study investigating the relationship between chronic tinnitus and peripheral blood derived BDNF/ GDNF promoter methylations Apr 30, 2019
- NEUROMOD VIDEO: “New Treatment for Tinnitus Evaluated in over 500 Patients” [Dr. Hubert Lim presentation] Apr 29, 2019
- Auris Medical Provides Update on Tinnitus Drug Development Strategy Apr 25, 2019
- Phase 1/2 clinical trial of OTO-313 (single intratympanic injection) in patients with subjective tinnitus is now recruiting Apr 17, 2019
- Otonomy Initiates Phase 1/2 Clinical Trial to evaluate the therapeutic potential of OTO-313 in patients with tinnitus Apr 11, 2019
- NIH awards NAU audiologist $455,982 to study genetic link to tinnitus Apr 10, 2019
- Biotech Frequency shows early positive results for small-molecule hearing loss therapy (FX-322) Apr 9, 2019
- Frequency Therapeutics Announces Positive Phase 1/2 Data for FX-322 Apr 9, 2019
Research
- Development of Ebselen for the Treatment of Sensorineural Hearing Loss and Tinnitus Feb 19, 2021
- Transient Delivery of a KCNQ2/3-Specific Channel Activator [RL-81] 1 Week After Noise Trauma Mitigates Noise-Induced Tinnitus Feb 11, 2021
- Using cortical neuron markers to target cells in the dorsal cochlear nucleus: new means for treatment of bothersome tinnitus? Feb 9, 2021
- Altering activity in the peripheral nerve may be a viable target for early pharmaceutical intervention in forms of tinnitus originating in the cochlea Feb 3, 2021
- Spontaneous firing patterns in the medial geniculate nucleus in a guinea pig model of tinnitus Jan 30, 2021
- Review: Neural Mechanisms of Tinnitus and Hyperacusis Jan 19, 2021
- Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus Jan 15, 2021
- Efficacy of fluoxetine vs. fluoxetine plus alprazolam in treatment of chronic tinnitus: No reduction in Tinnitus Severity Index (TSI) Jan 15, 2021
- Towards personalized rTMS in tinnitus: reliability of individualized stimulation protocols in behavioral and electrophysiological responses [Preprint] Jan 13, 2021
- Tinnitus-like “hallucinations” elicited by sensory deprivation in an entropy maximization recurrent neural network [Preprint] Jan 11, 2021
- Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus Jan 7, 2021
- Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma Jan 5, 2021
- Prediction of Acoustic Residual Inhibition of Tinnitus Using a Brain-Inspired Spiking Neural Network Model Jan 5, 2021
- Low-Level Laser Therapy as a Therapeutic Strategy for Patients With Tinnitus: Not Yet Proven Dec 29, 2020
- ATP-sensitive K+ channels control the spontaneous firing of a glycinergic interneuron in the auditory brainstem Dec 28, 2020
- Subcortical and cortical responses are enlarged in tinnitus patients with hyperacusis compared to those without hyperacusis Dec 24, 2020
- Systematic review and meta-analysis of late auditory evoked potentials as a candidate biomarker in the assessment of tinnitus Dec 17, 2020
- Neurophysiological correlates of residual inhibition in tinnitus: Hints for trait-like EEG power spectra Dec 16, 2020
- Gray matter declines with age and hearing loss, but is partially maintained in tinnitus Dec 11, 2020
- Purinergic signaling controls spontaneous activity in the auditory system throughout early development Dec 10, 2020
- A tale of two tinnituses: Does hearing status influence central tinnitus localization? Dec 3, 2020
- Efficacy of Low-Level Laser Therapy for Tinnitus: A Systematic Review with Meta-Analysis and Trial Sequential Analysis Dec 2, 2020
- Tinnitus and auditory cortex: using adapted functional near-infrared spectroscopy to measure resting-state functional connectivity Nov 27, 2020
- Association Between Tinnitus Pitch and Consonant Recognition in Noise Nov 25, 2020
- Switching Tinnitus-On: Maps and source localization of spontaneous EEG Nov 23, 2020
- Cannabinoids, Inner Ear, Hearing, and Tinnitus: A Neuroimmunological Perspective Nov 23, 2020
- A Gradient of Sharpening Effects by Perceptual Prior across the Human Cortical Hierarchy Nov 18, 2020
- Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning Nov 18, 2020
- Tinnitus impairs segregation of competing speech in normal-hearing listeners Nov 16, 2020
- Increased central gain caused by reduced auditory input is a major mechanism of tinnitus but may originate from other pathophysiologic factors rather than from cochlear synaptopathy Nov 10, 2020
- Tinnitus Symptoms Improve With Sound and Tongue Stimulation Nov 10, 2020
- What Makes Tinnitus Loud? Nov 8, 2020
- Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem Nov 5, 2020
- Effect of age on the gap-prepulse inhibition of the cortical N1-P2 complex in humans as a step towards an objective measure of tinnitus Nov 5, 2020
- Does the tinnitus pitch correlate with the frequency of hearing loss? Nov 4, 2020
- Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus Nov 3, 2020
- A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response Oct 30, 2020
- Dietary Factors and Tinnitus among Adolescents Oct 27, 2020
- The Prevalence of Different Types of Headache in Patients with Subjective Tinnitus and Its Influence on Tinnitus Parameters: A Prospective Clinical Study Oct 24, 2020
- Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus Oct 13, 2020
- Noise Induced Hearing Loss and Tinnitus-New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention Oct 13, 2020
- The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus Oct 9, 2020
- Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study Oct 7, 2020
- High Definition transcranial Direct Current Stimulation (HD-tDCS) for chronic tinnitus: outcomes from a prospective longitudinal large cohort study [Preprint] Oct 2, 2020
- Phenotyping chronic tinnitus patients using self-report questionnaire data: cluster analysis and visual comparison Oct 2, 2020
- How can sound generating devices support coping with tinnitus? Oct 1, 2020
- A New Buzz for Tinnitus—It’s in the Genes! Sep 24, 2020
- Novel Genetic Risk Loci Associated with Tinnitus and Causal Inference with Hearing Loss and Neuropsychiatric Disorders and Traits Sep 24, 2020
- Individualized Treatment of Tinnitus during Sleep Using Stimulation of the Auditory and Limbic Systems Sep 23, 2020
- Using cortical neuron markers to target cells in the dorsal cochlear nucleus: novel tools for studying tinnitus mechanisms [Preprint] Sep 20, 2020
- Perceptual Dimensions Underlying Tinnitus-Like Sounds Sep 18, 2020
- Dual-site rTMS is More Effective than Single-site rTMS in Tinnitus Patients: A Blinded Randomized Controlled Trial Sep 17, 2020
- The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants Sep 16, 2020
- Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study [Preprint] Sep 15, 2020
- Glutamatergic modulation of auditory cortex connectivity with attentional brain networks in unpredictable perceptual environment Sep 14, 2020
- Genetic variation in RCOR1 is associated with tinnitus in UK Biobank [Preprint] Sep 13, 2020
- From Acute to Chronic Tinnitus: Pilot Data on Predictors and Progression Sep 11, 2020
- Proteasome Activity in the Plasma as a Novel Biomarker in Mild Cognitive Impairment with Chronic Tinnitus Sep 11, 2020
- Mechanisms Underlying Enhancement of Spontaneous Glutamate Release by Group I mGluRs at a Central Auditory Synapse Sep 9, 2020
- Transcranial direct current stimulation improves tinnitus perception and modulates cortical electrical activity in patients with tinnitus: A randomized clinical trial Aug 28, 2020
- Loud noise exposure differentially affects subpopulations of auditory cortex pyramidal cells [Preprint] Aug 25, 2020
- Tinnitus severity significantly worse in patients with hearing loss than patients with normal hearing Aug 13, 2020
- Acupuncture for tinnitus: level of evidence insufficient to draw any definitive conclusions Aug 10, 2020
- Uncovering the Contribution of Enhanced Central Gain and Altered Cortical Oscillations to Tinnitus Generation Aug 9, 2020
- Susceptibility to Residual Inhibition is Associated with Hearing Loss and Tinnitus Chronicity [Preprint] Aug 6, 2020
- Single nucleotide polymorphisms in tinnitus patients exhibiting severe distress: severity of tinnitus is associated with genetic background Aug 3, 2020
- Analysis of cerebellum with magnetic resonance 3D T1 sequence in individuals with chronic subjective tinnitus Aug 3, 2020
- Association between Hyperacusis and Tinnitus Jul 28, 2020
- The Efficacy of Intratympanic Steroid Injection (Dexamethasone) in Tinnitus Cases Unresponsive to Medical Treatment Jul 28, 2020
- Analysis of Auditory Brainstem Response Change, according to Tinnitus Duration, in Patients with Tinnitus with Normal Hearing Jul 28, 2020
- Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus Jul 26, 2020
- Loss of Cochlear Ribbon Synapse Is a Critical Contributor to Chronic Salicylate Sodium Treatment-Induced Tinnitus without Change Hearing Threshold Jul 25, 2020
- Genetic Inheritance and Its Contribution to Tinnitus Jul 24, 2020
- A Case Report of High Cervical Spinal Cord Stimulation for Chronic Otalgia and Tinnitus Jul 23, 2020
- Increasing endogenous activity of NMDARs on GABAergic neurons prevents noise-induced tinnitus Jul 20, 2020
- Nitric oxide increases gain within the ventral cochlear nucleus of guinea pigs with tinnitus Jul 19, 2020
- Potential Role of Noninvasive Brain Stimulation Interventions (NIBS) in Tinnitus Management Jul 9, 2020
- The sound-sensitive tinnitus index: Psychometric properties of a scale to assess the impact of tinnitus exacerbated by sound Jul 9, 2020
- Fluctuations in Subjective Tinnitus Ratings Over Time: Implications for Clinical Research Jul 3, 2020
- Evidence of Reorganization of Brain White Matter in Persistent Idiopathic Tinnitus Patients Without Hearing Loss Suggests Close Relationship Between Tinnitus and Limbic System Jul 2, 2020
- Dorsomedial Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation (rTMS) for Tinnitus: Results of a Blinded, Randomized, Sham-Controlled Study Jul 2, 2020
- Auditory Neural Plasticity in Tinnitus Mechanisms and Management Jul 1, 2020
- Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss Jun 30, 2020
- Non-Invasive Neuromodulation for Tinnitus Jun 25, 2020
- Impact of Acamprosate on Chronic Tinnitus: a subjective relief of tinnitus as well as some degree of the electrophysiological improvement at the level of the cochlear and the distal portion of the auditory nerve among subjects who received acamprosate Jun 5, 2020
- High mean platelet volume and neutrophil to lymphocyte ratio values are associated with idiopathic tinnitus, suggesting the role of vascular pathologies in etiology of tinnitus Jun 4, 2020
- Improved pure tone sensitivity after simulated hearing loss [Preprint] May 31, 2020
- Transcutaneous Electrical Nerve Stimulation (TENS) for Treatment of Tinnitus: a safe and feasible intervention option May 28, 2020
- Altered Topological Patterns of Gray Matter Networks in Tinnitus: A Graph-Theoretical-Based Study May 27, 2020
- Associations Between Subjective Tinnitus and Cognitive Performance: Systematic Review and Meta-Analyses May 21, 2020
- Binaural Interaction in Tinnitus Patients: the presence of binaural processing deficits in tinnitus patients May 13, 2020
- Tinnitus associated with benzodiazepine withdrawal syndrome: a rare but debilitating and long-term risk May 7, 2020
- Avenue for Future Tinnitus Treatments May 4, 2020
- Heritability and Genetics Contribution to Tinnitus Apr 22, 2020
- Current Device-based Clinical Treatments for Tinnitus Apr 22, 2020
- Regulation of auditory plasticity during critical periods and following hearing loss: understanding the interplay of molecular and cellular mechanisms associating hearing loss-induced plasticity with tinnitus will enable the development of more effective, reliable, and personalized treatments for tinnitus Apr 20, 2020
- Microstate in resting state: an EEG indicator of tinnitus? Apr 17, 2020
- The Stochastic Resonance model of auditory perception: A unified explanation of tinnitus development, Zwicker tone illusion, and residual inhibition Mar 29, 2020
- Cortical Tonotopic Map Changes in Humans are Larger in Hearing Loss than in additional Tinnitus Mar 19, 2020
- Investigating functional changes in the brain to intermittently induced auditory illusions and its relevance to chronic tinnitus Mar 10, 2020
- Relationship Between Diet, Tinnitus, and Hearing Difficulties: Higher intakes of calcium, iron and fat were associated with increased odds of tinnitus while higher intakes of vitamin B12 and dietary pattern factor 3 (High protein) were associated with reduced odds of tinnitus Mar 1, 2020
- Effects of Vibrant Soundbridge (VSB) on Tinnitus Accompanied by Sensorineural Hearing Loss Feb 4, 2020
- Beyond Hearing Loss: Does Tinnitus Cause Cognitive Impairment? Feb 1, 2020
- Plasticity in Limbic Regions at Early Time Points in Experimental Models of Tinnitus Jan 24, 2020
- A mouse model for temporary and persistent tinnitus using the gap startle paradigm Jan 22, 2020
- Is there an association between the parameters of arterial stiffness and tinnitus? Jan 13, 2020
- A 7 Tesla fMRI Investigation of Human Tinnitus Percept in Cortical and Subcortical Auditory Areas Jan 11, 2020
- Perceptual Modeling of Tinnitus Pitch and Loudness Jan 8, 2020
- Single dose of hallucinogenic compound 5-MeO-DMT can be effective in treating tinnitus-related anxiety Jan 8, 2020
- Cognitive behavioural therapy for tinnitus: uncertainty remains due to concerns about quality of evidence and an absence of evidence at 6 or 12 months follow-up Jan 8, 2020
- A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity Jan 6, 2020
- Amplitude Modulated Noise for Tinnitus Suppression in Tonal and Noise-Like Tinnitus Jan 6, 2020
- The effect of fibromyalgia treatment on tinnitus Jan 3, 2020
- Altered functional connectivity of the thalamus in tinnitus patients is correlated with symptom alleviation after sound therapy Jan 3, 2020
- Within-Subject Analysis of Auditory Brain Stem Responses in Adults With Unilateral Tinnitus Dec 26, 2019
- Ginkgo biloba for tinnitus – Cochrane Database of Systematic Reviews Dec 23, 2019
- Findings support a striatal gating model of tinnitus and suggest tinnitus biomarkers to monitor treatment response and to target specific brain areas for innovative neuromodulation therapies Dec 20, 2019
- Abnormal Spontaneous Neural Activity of the Central Auditory System Changes the Functional Connectivity in the Tinnitus Brain Dec 20, 2019
- Enhancement of VGLUT3 expression in cochlear inner hair cells may contribute to the pathogenesis of tinnitus Dec 19, 2019
- Analysis of the audiological characteristics and comorbidity in patients with chronic tinnitus Dec 19, 2019
- Morphological Neuroimaging Biomarkers for Tinnitus: Evidence Obtained by Applying Machine Learning Dec 13, 2019
- The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial Dec 12, 2019
- Treatment Outcome of Auditory and Frontal Dual-Site rTMS in Tinnitus Patients: A beneficial effect of rTMS on tinnitus suppression Dec 12, 2019
- Exposing Pathological Sensory Predictions in Tinnitus Using Auditory Intensity Deviant Evoked Responses: An introduction to Intensity Mismatch Asymmetry (IMA), a new tinnitus biomarker based on a prediction resetting model of tinnitus generation Dec 11, 2019
- A proof-of-principle study of the short-term effects of MDMA (3,4-methylenedioxymethamphetamine) on tinnitus and neural connectivity Dec 7, 2019
- Chronic Tinnitus Exhibits Bidirectional Functional Dysconnectivity in Frontostriatal Circuit Dec 6, 2019
- Blast Trauma-Induced Tinnitus vs. Noise Trauma-Induced Tinnitus: Similarities and Differences Nov 27, 2019
- Medicines discovery for auditory disorders (including potential treatments for tinnitus): Challenges for industry Nov 27, 2019
- Real-time monitoring and regulating auditory cortex alpha activity in patients with chronic tinnitus Nov 14, 2019
- Tinnitus and event related potentials: a systematic review Nov 4, 2019
- Maladaptive alterations of resting state cortical network in Tinnitus Oct 29, 2019
- The effect of transcutaneous electrical nerve stimulation (TENS) on chronic subjective tinnitus Oct 29, 2019
- Missed Hearing Loss in Tinnitus Patients With Normal Audiograms Oct 17, 2019
- Noninvasive Bimodal Neuromodulation for the Treatment of Tinnitus: Protocol for a Second Large-Scale Double-Blind Randomized Clinical Trial to Optimize Stimulation Parameters Sep 27, 2019
- Efficacy and safety of bilateral caudate nucleus deep brain stimulation (DBS) for treatment-resistant tinnitus Sep 24, 2019
- Tinnitus disrupts the functioning of auditory working memory Sep 21, 2019
- Hidden hearing loss and tinnitus: utility of the high-definition audiograms in diagnosis Sep 19, 2019
- Invasive Neuromodulation as a Treatment for Tinnitus: A Systematic Review Sep 16, 2019
- Auditory Brainstem Response in Patients With Tinnitus Associated With Vitamin B12 Deficiency Sep 15, 2019
- A Prospective Study to Evaluate Effectiveness of a Tinnitus Relief Device (TRx) in a Clinical Setup Sep 4, 2019
- Outcomes of Triple-Combination Therapy for Chronic Tinnitus Sep 1, 2019
- Memantine Attenuates Salicylate-induced Tinnitus Possibly by Reducing NR2B Expression in Auditory Cortex of Rat Aug 31, 2019
- Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus Aug 14, 2019
- Why Is There No Cure for Tinnitus? Current Obstacles and the New Roadmap Toward a Cure Aug 6, 2019
- Sound therapy (using amplification devices and/or sound generators) for tinnitus: insufficient evidence of improvement over placebo Jul 30, 2019
- Toward An Exploration of Habituating to Tinnitus: Perspectives on Sensory Gating Jul 12, 2019
- Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies Jul 3, 2019
- Mechanism of acupuncture efficacy on tinnitus: acupuncture associated with improvement of cochlear blood flow via infrared thermography test Jun 26, 2019
- Toward Personalized Tinnitus Treatment: An Exploratory Study Based on Internet Crowdsensing Jun 25, 2019
- Treatment of Tinnitus Using Theta Burst Based Repetitive Transcranial Magnetic Stimulation-A Single Blinded Randomized Control Trial Jun 22, 2019
- Specific connectivity with Operculum 3 (OP3) brain region in acoustic trauma tinnitus Jun 20, 2019
- Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models Jun 18, 2019
- Effect of electrical stimulation at auricular points combined with sound masking on the expression of CREB, BDNF and TrkB in the auditory cortex of tinnitus rats Jun 12, 2019
- Effect of Tinnitus Retraining Therapy vs Standard of Care on Tinnitus-Related Quality of Life: A Randomized Clinical Trial May 23, 2019
- Changes in gene expression following sudden loss of auditory input in one ear may contribute to perceptual disorders such as tinnitus and hyperacusis May 21, 2019
- Tinnitus-related hyper-excitation is suppressed by inhibitory dual-site repetitive transcranial magnetic stimulation (rTMS) May 15, 2019
- The short-term effects of recorded ocean sound with and without alpha frequency binaural beats on tinnitus perception May 8, 2019
- Relationship between chronic tinnitus and peripheral blood derived BDNF/GDNF promoter methylations Apr 30, 2019
- Key Findings From Tinnitus Research and Clinical Implications Apr 25, 2019
- Development of a novel middle-ear electrode for tinnitus suppression – proof of concept Apr 23, 2019
- Analysis of tinnitus patients’ hearing loss validates hypothesis on tinnitus development Apr 23, 2019
- Editorial: Translating Tinnitus Research Findings Into Clinical Practice Apr 22, 2019
- The Role of the Brainstem in Generating and Modulating Tinnitus Apr 22, 2019
- What is the difference between intermittent tinnitus and continuous tinnitus? Apr 15, 2019
- Prediction and perception: Insights for (and from) tinnitus Apr 15, 2019
- An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders Affecting Hearing, Balance and Tinnitus Pathways Apr 10, 2019
- Complementary and Alternative Treatments for Tinnitus Apr 3, 2019
- Ethnobotanical Study of Medicinal Plants Used in Central Macedonia, Greece [Satureja montana subsp. macedonica for tinnitus and hearing loss] Apr 1, 2019
- Advances in Understanding, Diagnosis, and Treatment of Tinnitus: a Review Mar 27, 2019
- Efficacy and safety of AUT00063 versus placebo in subjective tinnitus: AUT00063 was not effective in alleviating tinnitus symptoms Mar 27, 2019
- Tinnitus Research: Improvement and Innovation Mar 24, 2019
- The potential role of auditory prediction error in preventing habituation to tinnitus Mar 20, 2019
- Effects of oral zinc supplementation on patients with noise-induced hearing loss associated tinnitus: no improvements? Mar 20, 2019
- Molecular Aspects of Melatonin Treatment in Tinnitus: a Review Mar 19, 2019
- Earplug-induced changes in acoustic reflex thresholds suggest that increased subcortical neural gain may be necessary but not sufficient for the occurrence of tinnitus Mar 16, 2019
- Comparison of Amplitude Modulated Sounds and Pure Tones at the Tinnitus Frequency: Residual Tinnitus Suppression and Stimulus Evaluation Mar 15, 2019
- Alleviation of Tinnitus With High-Frequency Stimulation of the Dorsal Cochlear Nucleus: A Rodent Study Mar 14, 2019
- Frequency-specifc activation of the peripheral auditory system using optoacoustic laser stimulation [Hubert Lim] Mar 12, 2019
- Do dietary factors significantly influence tinnitus? Mar 5, 2019
- Towards a Mechanistic-Driven Precision Medicine Approach for Tinnitus Mar 1, 2019
- Managing Patient—and Audiologist—Expectations for Tinnitus Treatment Mar 1, 2019
- AM-111 improved hearing but showed no impact on tinnitus Mar 1, 2019
- Clinical trial on tinnitus patients with normal to mild hearing loss: broad band noise and mixed pure tones sound therapy Feb 26, 2019
- Odds of tinnitus progression is highest for patients with combined low and high frequency hearing loss Feb 22, 2019
- Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation Feb 19, 2019
- Human caudate nucleus subdivisions in tinnitus modulation Feb 8, 2019
- Neuroprotective effects of MK-801 on auditory cortex in salicylate-induced tinnitus: Involvement of neural activity, glutamate and ascorbate Feb 1, 2019
- Residual inhibition: from the putative mechanisms to potential tinnitus treatment Feb 1, 2019
- Clinical review: The therapeutic use of theta-burst stimulation in mental disorders and tinnitus Jan 29, 2019
- Personalizing Neuromodulation Jan 24, 2019
- Single session anodal, cathodal and placebo bifrontal tDCS for treatment of intractable chronic tinnitus: A randomized controlled clinical trial Jan 22, 2019
- Adjunctive Role of Bifrontal Transcranial Direct Current Stimulation in Distressed Patients with Severe Tinnitus Jan 21, 2019
- Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC) Jan 17, 2019
- Low-intensity repetitive transcranial magnetic stimulation over prefrontal cortex in an animal model alters activity in the auditory thalamus but does not affect behavioural measures of tinnitus Jan 16, 2019
- Tinnitus Treatment Using Noninvasive and Minimally Invasive Electric Stimulation: Experimental Design and Feasibility Jan 9, 2019
- Aberrant Thalamocortical Coherence in Animal Model of Tinnitus Jan 9, 2019
- Neuronavigated Versus Non-navigated Repetitive Transcranial Magnetic Stimulation for Chronic Tinnitus: A Randomized Study Jan 7, 2019
- Does Transcranial Direct Current Stimulation Have a Role in the Treatment of Tinnitus? Jan 2, 2019
- A Pilot Randomized Controlled Trial of Transcutaneous Electrical Nerve Stimulation for Patients With Acute Tinnitus Jan 1, 2019
- Betahistine for tinnitus: no evidence to suggest an effect on tinnitus, when compared to placebo Dec 28, 2018
Clinical Trials
- Daily Bitemporal Low-frequency Transcranial Random Noise Stimulation in Tinnitus (tRNS2-tin) Jan 20, 2021
- Acoustic and Electrical Stimulation for the Treatment of Tinnitus Jan 14, 2021
- Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts Nov 13, 2020
- Investigating Accelerated Learning in Tinnitus Participants Implanted With Vagus Nerve Stimulation [Suspended] Nov 4, 2020
- Novel Tinnitus Implant System for the Treatment of Chronic Severe Tinnitus Oct 19, 2020
- Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus Sep 29, 2020
- Transcranial Electrical and Acoustic Stimulation for Tinnitus Sep 16, 2020
- ICCAC-ToNF EEG Neurofeedback Training & Tinnitus Sep 4, 2020
- MRI Study of Noninvasive Transcranial Electrical Stimulation in Tinnitus Aug 31, 2020
- High Dose Oxytocin Nasal Spray for Treatment of Tinnitus Aug 14, 2020
- An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus Jul 8, 2020
- OTO-313 in Subjects With Subjective Tinnitus [Completed] Jun 17, 2020
- Treatment of Tinnitus With Migraine Medications May 27, 2020
- Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus May 22, 2020
- Deep Brain Stimulation for Tinnitus Mar 23, 2020
- Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS) Mar 5, 2020
- Phase 2a Efficacy Study of FX-322 in Adults With Stable Sensorineural Hearing Loss Jan 29, 2020
- Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation [Terminated] Dec 19, 2019
- Novel Tinnitus Implant System for the Treatment of Chronic Severe Tinnitus Nov 19, 2019
- Effects of Sound Stimulation, Somatosensory Stimulation, Vestibular Stimulation and the Combinations on Tinnitus Loudness and Tinnitus Related Distress in Patients Oct 8, 2019
- A Phase-II Clinical Trial on the Effectiveness of Antioxidant Supplementation in Idiopathic Tinnitus Patients [Completed] Sep 26, 2019
- Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral Tinnitus May 30, 2019
- Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation May 21, 2019
- Treatment Evaluation of Neuromodulation for Tinnitus – Stage A2 (TENT-A2) [Neuromod] Apr 30, 2019
- Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus [Withdrawn (Lack of funding and personnel)] Apr 29, 2019
- FX-322 in Sensorineural Hearing Loss [Completed] Apr 10, 2019
- Experimental Tinnitus Treatment With Transcranial Magnetic Stimulation Feb 6, 2019
- Treatment Evaluation of Neuromodulation for Tinnitus (TENT-A) [Neuromod] Jan 1, 2019
- Effects of Kinesio Taping in Patients With Somatosensory Tinnitus Dec 20, 2018
- Cochlear Promontory Stimulation for Treatment of Tinnitus Nov 30, 2018
- Regulating Homeostatic Plasticity and the Physiological Response to rTMS Nov 28, 2018
- Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts [Susan Shore] Nov 12, 2018
- The Study of Wuling Capsule in Treatment Chronic Tinnitus Sep 18, 2018
