Tinnitus Treatment Report

New and Upcoming
Treatments for Tinnitus

This page tracks new and upcoming treatment options for tinnitus. What’s in development? What’s promising? What’s available soon? Current topics include CS0022 (BMS-191011), FX-322, OTO-313, Susan Shore device, NHPN-1010, Lenire, GW-201 (GW-TT1), Jianxin Bao, tetrandrine, OtoBand, Sulodexide, 6B-001, and more.

Last Updated: March 16, 2023

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News

Sage Therapeutics Starting Phase 2 Study of SAGE-547 (6-hour infusion drug) for Treating Tinnitus December 9, 2022
New Anti-Tinnitus Drugs May Target Vasoactive Intestinal Peptide (VIP) Excitability November 29, 2022
BREAKING: Otonomy Completes Phase 2 Clinical Trial of OTO-313 for Tinnitus… July 9, 2022
NEOMED Researchers Explore Chemogenetic Modulators for Treatment of Chronic Tinnitus June 13, 2022
RespireRx Pharmaceuticals Highlights Potential Use of GABAkine Neuromodulators for Treatment of Tinnitus May 16, 2022
Neuromod Initiates Stage 3 (TENT-A3) Clinical Trial of Lenire Device for Tinnitus Treatment February 7, 2022
D-serine and its signaling pathway may represent a new druggable target for treating tinnitus January 15, 2022
Phase 3 Clinical Trial of OTO-313 for Tinnitus Expected to Start in First Half of 2023 January 6, 2022
Otonomy Announces Publication of Phase 1/2 Trial Results Showing Tinnitus Improvement in Patients Receiving OTO-313 October 12, 2021
Susan Shore’s New “Auricle Device” for Tinnitus Is Almost Ready for Commercial Release… September 7, 2021
July 2021 update on Cognosetta’s tinnitus drug: CS0022 July 21, 2021
Anti-Tinnitus Effects of “Prism Adaptation” Glasses: Researchers in France to Begin Major Study Next Month (August 2021) July 9, 2021
Impact of Sazetidine-A and Similar Nicotinic Drugs on Tinnitus June 23, 2021
Sulodexide Anticoagulant Therapy for Chronic Tinnitus: Phase 3 Clinical Trials — When? June 18, 2021
Thanos Tzounopoulos explains the current state of tinnitus drug development research (and the crucial missing piece) June 3, 2021
Brian Fargo, inXile founder, gives $1 million to advance UCI research for tinnitus treatment May 19, 2021
Efficacy of donepezil in patients with chronic tinnitus May 17, 2021
Ketamine + HD-tIPNS for tinnitus: Professor Dirk De Ridder investigates effects of new “drug/device combo” therapy May 12, 2021
University of Granada researchers identify genes linked to severe tinnitus April 29, 2021
Researchers evaluating the effects of bitter almond oil and cinnarizine on chronic tinnitus severity April 26, 2021
Otonomy Now Recruiting Participants for Phase 2 Study of OTO-313 in Tinnitus [Update: New Locations Added] April 11, 2021
Otonomy Initiates Phase 2 Clinical Trial of OTO-313 in Tinnitus March 25, 2021
MISSING: Day-90 Study Results on Impact of FX-322 on Tinnitus… March 25, 2021
American Tinnitus Association Seeking Tinnitus Research Proposals… “that may contribute to scientific understanding of tinnitus, breakthroughs in treatments, and possible cures” March 12, 2021
Otolith Labs Initiates Clinical Trial of OtoBand Device as a Treatment to Reduce Perceived Loudness of Tinnitus March 8, 2021
Frequency Therapeutics Announces Publication of Phase 1/2 Data Showing Hearing Improvements in Patients Receiving FX-322 February 22, 2021
Otonomy Shifts Focus to Hearing Loss and Tinnitus [OTO-313] After Meniere’s Phase III Failure February 22, 2021
Novel Tinnitus Drug CS0022 Reduces Chronic Tinnitus in Preclinical Study February 8, 2021
Discovery of a New Type of Inhibitory Neuron [L-stellate cells] Holds Clues About Tinnitus February 4, 2021
BREAKTHROUGH: NAC/HPN-07, also known as the Hough Ear Institute’s NHPN-1010, significantly reduced the incidence of tinnitus, study finds… January 7, 2021
American Tinnitus Association Receives $2.7 Million Donation – Money Will Help Fund Strategic Long-Term Tinnitus Research December 26, 2020
Hubert Lim on Neuromodulation and Research Behind the Lenire Device for Tinnitus [PDF] December 14, 2020
What can biobanks bring to hearing, and in particular to tinnitus? December 4, 2020
British Tinnitus Association awards £125k grant for research that could predict who will develop tinnitus December 4, 2020
Otonomy expects to start Phase 2 trial of OTO-313 in tinnitus in first quarter of 2021 November 30, 2020
In Case You Missed It: Tinnitus Hub Director Hazel Goedhart gives us the cold, hard, unbiased facts about Lenire… November 24, 2020
Researchers Develop New Technology to Objectively Measure Tinnitus November 19, 2020
Technology lets clinicians objectively detect tinnitus for first time November 18, 2020
New FX-322 clinical trial for severe hearing loss includes tinnitus assessment as secondary outcome measure November 16, 2020
The role of prediction and gain in tinnitus November 2, 2020
Frequency Therapeutics Will Report FX-322 Phase 2a Study Data in Late Q1 2021 October 29, 2020
Neuromod Successfully Closes $12.4 Million Series B Financing for Tinnitus Treatment Device Lenire® October 20, 2020
Auckland University researchers trialing MDMA as tinnitus cure October 17, 2020
Heavy metals could play important role in development of tinnitus, study finds October 12, 2020
New Treatment Alleviates Ringing in the Ears: A noninvasive device [Lenire] designed to rewire brain circuits reduced symptoms of tinnitus in a large clinical trial October 7, 2020
Is tinnitus all in the genes? September 25, 2020
How much will FX-322 cost? David Lucchino, Frequency Therapeutics CEO, responds… September 24, 2020
Frequency Therapeutics Completes Enrollment of FX-322 Phase 2a Study for Sensorineural Hearing Loss September 22, 2020
Proposed “Multi-Cause Framework” of Tinnitus May Speed Up Development of New Therapies September 17, 2020
Possible tinnitus gene found: Genetic variation in RCOR1 is associated with tinnitus September 14, 2020
Frequency Therapeutics Presents Results Demonstrating Sustained Improvement in Hearing Loss Patients Treated with FX-322 September 13, 2020
First report showing benefit of spinal cord stimulation in tinnitus September 12, 2020
Dr. Will Sedley discusses role of “predictive brain processing” in tinnitus – via Tinnitus Talk [PDF] September 7, 2020
British Tinnitus Association’s 2020 Tinnitus Conference Goes Virtual: October 5 – 9 August 27, 2020
Not-yet-published tinnitus research preprints… August 26, 2020
FX-322 phase 2a study results anticipated in second quarter of 2021… August 12, 2020
Carl LeBel (Chief Development Officer at Frequency Therapeutics) talks FX-322 in latest interview – via Tinnitus Talk [PDF] July 25, 2020
Update on new tinnitus drug (GW-201) from NEOMED researcher Jianxin Bao and Gateway Biotechnology July 20, 2020
NEOMED researcher receives federal grant for first human tinnitus treatment July 15, 2020
NIH Funds NEOMED Tinnitus Researcher July 8, 2020
Otonomy Reports Positive Top-Line Results from Phase 1/2 Clinical Trial of OTO-313 in Patients with Tinnitus July 6, 2020
Otonomy Provides Update on Clinical Trials: Results from Phase 1/2 trial of OTO-313 for tinnitus expected in July 2020 June 15, 2020
Congressman Announces National Institute on Deafness and Other Communications Disorders Grant for Tinnitus Prevention and Treatment June 11, 2020
Frequency Therapeutics Shares Clinical Data From Exploratory Study Confirming Delivery of FX-322 to the Cochlea – Top-Line Results Show Consistent Drug Entry in All Patients May 14, 2020
FAU researchers use computer-based ‘stochastic resonance’ model of tinnitus as a basis for developing new treatment strategies May 13, 2020
Updated list of hearing loss treatment news and research available at HearingLossTreatmentReport.com May 1, 2020
Tinnitus Research Spotlight: A unified explanation of tinnitus development based on the Stochastic Resonance (SR) model of auditory perception April 21, 2020
NO COVID-19 SLOWDOWN: Frequency Therapeutics Adds Another Recruitment Site for FX-322 Phase 2a Study (HearingLossTreatmentReport.com) April 14, 2020
Treatments for tinnitus may need to enhance cortical plasticity rather than reverse it… March 24, 2020
Study findings demonstrate that Lenire (Neuromod) for tinnitus “provides safe, fast-acting (within 6 weeks) and reproducible therapeutic effects that can last at least 12 months.” March 11, 2020
Toward Tinnitus Subtyping: or Finding a Specific Personalized Treatment for Each Patient February 15, 2020
Why Tinnitus Needs Citizen Science: A Researcher’s Perspective February 8, 2020
Developing effective treatments or even a cure for tinnitus February 3, 2020
Resaphene Suisse AG: Charité Ethics Committee in Berlin Approves Study on Tinniwell Tinnitus Therapy January 21, 2020
Cognosetta, Inc receives funding from NIH to test a novel therapeutic for treating tinnitus (BMS-191011) January 14, 2020
New ‘fast-track’ system for tinnitus and hearing loss January 10, 2020
Auris Medical Receives “Intention to Grant” notice from European Patent Office for New Oral NKCC1 inhibitor Treatment for Tinnitus January 10, 2020
Zilentin: Auris Medical Announces Formation of New Subsidiary for Development Projects in Tinnitus and Hearing Loss December 30, 2019
American Tinnitus Association and British Tinnitus Association Partner to Spark Innovations in Tinnitus Treatments and Advance Global Discussion About Potential Tinnitus Breakthroughs December 10, 2019
Proof of concept to support MDMA as a potential treatment for tinnitus? December 10, 2019
Frequency Therapeutics CEO: “We have opened all U.S. sites for our Phase 2a study of FX-322 and remain on track to report top-line data in the second half of next year.” November 18, 2019
RESEARCH: Experimental procedure enables suppression of auditory cortex alpha activity in patients with chronic tinnitus November 17, 2019
Neuromodulation for Tinnitus Relief: Interview with Neuromod Devices CEO Dr. Ross O’Neill October 24, 2019
The cortisol awakening response: could this be an effective measure of tinnitus distress? October 23, 2019
FDA Grants FX-322 Fast Track Designation October 10, 2019
Frequency Therapeutics Begins Recruiting for Phase 2 Study of FX-322 in Patients with Sensorineural Hearing Loss October 9, 2019
VIDEO: Susan Shore on Bimodal Stimulation for Tinnitus – #TRI2019 (via TinnitusHub) October 8, 2019
Neuromod (Lenire) Clinical Trial Data “Locked” Until Fall 2020? Study Results “Delayed” Until 2021? October 3, 2019
Neuromod Successfully Closes €8 Million Capital Raise: proceeds will be used to accelerate ongoing commercialization of Lenire® tinnitus treatment device September 26, 2019
A Breakthrough in Understanding Tinnitus: The Entire Hearing System Studied September 25, 2019
Possible Link Between Marijuana Use, Tinnitus September 16, 2019
Auris Medical Receives FDA and EMA Guidance for Keyzilen® (AM-101) Late-Stage Clinical Development Program September 13, 2019
ABSTRACT: Phase 1/2 Hearing Loss Trial of Intratympanic FX322, a Progenitor Cell Activator September 11, 2019
BREAKING: FX-322 Clinical Trial Results… September 6, 2019
Auris Medical Announces Formation of Scientific Advisory Board for Tinnitus Programs August 26, 2019
UA Rodent Study Identifies Possible Tinnitus Treatment Target August 26, 2019
Brain Inflammation Identified as Potential Target to Treat Tinnitus August 20, 2019
Tinnitus Cure Map from the British Tinnitus Association [image] August 6, 2019
Frequency Therapeutics prepares to advance first-in-class drug candidate FX-322 into Phase 2a study… July 23, 2019
Otonomy Expands Recruiting Locations for Phase 1/2 Clinical Trial of OTO-313 in Patients with Subjective Tinnitus July 20, 2019

Research

Association of Plasma Metabolomic Biomarkers With Persistent Tinnitus March 16, 2023
Extreme meteorological conditions are associated with tinnitus-related EV rates March 1, 2023
Efficacy and safety of acupuncture and moxibustion for primary tinnitus: A systematic review and meta-analysis February 26, 2023
Auditory Mirror Therapy for Tinnitus: A Pilot Study November 18, 2022
Therapeutic effects of Rosa Canina, Urtica Dioica and Tanacetum Vulgare Herbal Combination in Treatment of Tinnitus Symptoms; A Double-blind Randomized Clinical Trial October 21, 2022
Using prism adaptation to alleviate perception of unilateral tinnitus: A case study October 1, 2022
Cell-type-specific roles of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage September 15, 2022
Different bimodal neuromodulation settings reduce tinnitus symptoms in a large randomized trial June 30, 2022
Decreasing dorsal cochlear nucleus activity ameliorates noise-induced tinnitus perception in mice May 12, 2022
Can GABAkines Quiet the Noise? The GABAA Receptor Neurobiology and Pharmacology of Tinnitus April 30, 2022
The Quantum Tunneling of Ions Model Can Explain the Pathophysiology of Tinnitus March 23, 2022
The Road Traveled and Journey Ahead for the Genetics and Genomics of Tinnitus February 15, 2022
Electric hearing and tinnitus suppression by noninvasive ear stimulation January 5, 2022
Potential inflammatory biomarkers for tinnitus in platelets and leukocytes January 3, 2022
Intratympanic Administration of OTO-313 Reduces Tinnitus in Patients With Moderate to Severe, Persistent Tinnitus: A Phase 1/2 Study October 8, 2021
Striatal networks for tinnitus treatment targeting October 5, 2021
Effects of two inhibitors of metabolic glutamate receptor 5 on mice with tinnitus September 21, 2021
The role of vitamin D in subjective tinnitus: findings suggest vitamin D level correlates with tinnitus impact August 18, 2021
Efficacy of pharmacologic treatment in tinnitus patients without specific or treatable origin August 13, 2021
Simulated transient hearing loss improves auditory sensitivity July 20, 2021
Review of Pharmacotherapy for Tinnitus June 21, 2021
The Neuroscience and the Treatment of Tinnitus: what is the crucial missing piece in tinnitus research? May 28, 2021
Insufficient Evidence: Gabapentin’s Efficacy in Tinnitus Treatment – A Systematic Review May 26, 2021
Role of microRNA‑375‑3p‑mediated regulation in tinnitus development May 21, 2021
Cochlear nucleus small cells use olivocochlear collaterals to encode sounds in noise [Preprint] [Susan Shore] May 21, 2021
Auditory thalamus dysfunction and pathophysiology in tinnitus: a predictive network hypothesis May 2, 2021
The bewitched ear: State of the art genomics research on tinnitus April 24, 2021
Activity of CaMKIIa+ dorsal cochlear nucleus neurons are crucial for tinnitus perception but not for tinnitus induction [Preprint] April 8, 2021
Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study April 1, 2021
What’s the Buzz? The Neuroscience and the Treatment of Tinnitus [Thanos Tzounopoulos] March 26, 2021
Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank March 19, 2021
Effectiveness of photobiomodulation in the management of tinnitus remains debatable: A systematic review March 5, 2021
Increased Serum Lipid Levels in Patients with Subjective Tinnitus February 21, 2021
Development of Ebselen for the Treatment of Sensorineural Hearing Loss and Tinnitus February 19, 2021
The progression of chronic tinnitus over the years February 18, 2021
Pharmacological Evaluation of Drugs in Animal Models of Tinnitus February 16, 2021
Transient Delivery of a KCNQ2/3-Specific Channel Activator [RL-81] 1 Week After Noise Trauma Mitigates Noise-Induced Tinnitus February 11, 2021
Using cortical neuron markers to target cells in the dorsal cochlear nucleus: new means for treatment of bothersome tinnitus? February 9, 2021
Glucose Control Has an Impact on Cerebral Blood Flow Alterations in Chronic Tinnitus Patients February 4, 2021
Altering activity in the peripheral nerve may be a viable target for early pharmaceutical intervention in forms of tinnitus originating in the cochlea February 3, 2021
Spontaneous firing patterns in the medial geniculate nucleus in a guinea pig model of tinnitus January 30, 2021
The BDNF Val66 Met polymorphism regulates vulnerability to chronic stress and phantom perception January 22, 2021
Metabolic changes in the brain and blood of rats following acoustic trauma, tinnitus and hyperacusis January 19, 2021
Review: Neural Mechanisms of Tinnitus and Hyperacusis January 19, 2021
Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus January 15, 2021
Efficacy of fluoxetine vs. fluoxetine plus alprazolam in treatment of chronic tinnitus: No reduction in Tinnitus Severity Index (TSI) January 15, 2021
Towards personalized rTMS in tinnitus: reliability of individualized stimulation protocols in behavioral and electrophysiological responses [Preprint] January 13, 2021
Tinnitus-like “hallucinations” elicited by sensory deprivation in an entropy maximization recurrent neural network [Preprint] January 11, 2021
Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus January 7, 2021
Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma January 5, 2021
Prediction of Acoustic Residual Inhibition of Tinnitus Using a Brain-Inspired Spiking Neural Network Model January 5, 2021
Low-Level Laser Therapy as a Therapeutic Strategy for Patients With Tinnitus: Not Yet Proven December 29, 2020
ATP-sensitive K+ channels control the spontaneous firing of a glycinergic interneuron in the auditory brainstem December 28, 2020
Subcortical and cortical responses are enlarged in tinnitus patients with hyperacusis compared to those without hyperacusis December 24, 2020
Systematic review and meta-analysis of late auditory evoked potentials as a candidate biomarker in the assessment of tinnitus December 17, 2020
Neurophysiological correlates of residual inhibition in tinnitus: Hints for trait-like EEG power spectra December 16, 2020
Gray matter declines with age and hearing loss, but is partially maintained in tinnitus December 11, 2020
Purinergic signaling controls spontaneous activity in the auditory system throughout early development December 10, 2020
A Review and a Framework of Variables for Defining and Characterizing Tinnitus Subphenotypes December 4, 2020
A tale of two tinnituses: Does hearing status influence central tinnitus localization? December 3, 2020
Efficacy of Low-Level Laser Therapy for Tinnitus: A Systematic Review with Meta-Analysis and Trial Sequential Analysis December 2, 2020
Tinnitus and auditory cortex: using adapted functional near-infrared spectroscopy to measure resting-state functional connectivity November 27, 2020
Association Between Tinnitus Pitch and Consonant Recognition in Noise November 25, 2020
Switching Tinnitus-On: Maps and source localization of spontaneous EEG November 23, 2020
Cannabinoids, Inner Ear, Hearing, and Tinnitus: A Neuroimmunological Perspective November 23, 2020
A Gradient of Sharpening Effects by Perceptual Prior across the Human Cortical Hierarchy November 18, 2020
Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning November 18, 2020
Tinnitus impairs segregation of competing speech in normal-hearing listeners November 16, 2020
Increased central gain caused by reduced auditory input is a major mechanism of tinnitus but may originate from other pathophysiologic factors rather than from cochlear synaptopathy November 10, 2020
Tinnitus Symptoms Improve With Sound and Tongue Stimulation November 10, 2020
What Makes Tinnitus Loud? November 8, 2020
Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem November 5, 2020
Effect of age on the gap-prepulse inhibition of the cortical N1-P2 complex in humans as a step towards an objective measure of tinnitus November 5, 2020
Does the tinnitus pitch correlate with the frequency of hearing loss? November 4, 2020
Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus November 3, 2020
A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response October 30, 2020
Dietary Factors and Tinnitus among Adolescents October 27, 2020
The Prevalence of Different Types of Headache in Patients with Subjective Tinnitus and Its Influence on Tinnitus Parameters: A Prospective Clinical Study October 24, 2020
Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus October 13, 2020
Noise Induced Hearing Loss and Tinnitus-New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention October 13, 2020
The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus October 9, 2020
Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study October 7, 2020
High Definition transcranial Direct Current Stimulation (HD-tDCS) for chronic tinnitus: outcomes from a prospective longitudinal large cohort study [Preprint] October 2, 2020
Phenotyping chronic tinnitus patients using self-report questionnaire data: cluster analysis and visual comparison October 2, 2020
How can sound generating devices support coping with tinnitus? October 1, 2020
A New Buzz for Tinnitus—It’s in the Genes! September 24, 2020
Novel Genetic Risk Loci Associated with Tinnitus and Causal Inference with Hearing Loss and Neuropsychiatric Disorders and Traits September 24, 2020
Individualized Treatment of Tinnitus during Sleep Using Stimulation of the Auditory and Limbic Systems September 23, 2020
Using cortical neuron markers to target cells in the dorsal cochlear nucleus: novel tools for studying tinnitus mechanisms [Preprint] September 20, 2020
Perceptual Dimensions Underlying Tinnitus-Like Sounds September 18, 2020
Dual-site rTMS is More Effective than Single-site rTMS in Tinnitus Patients: A Blinded Randomized Controlled Trial September 17, 2020
The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants September 16, 2020
Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study [Preprint] September 15, 2020
Glutamatergic modulation of auditory cortex connectivity with attentional brain networks in unpredictable perceptual environment September 14, 2020
Genetic variation in RCOR1 is associated with tinnitus in UK Biobank [Preprint] September 13, 2020
From Acute to Chronic Tinnitus: Pilot Data on Predictors and Progression September 11, 2020
Proteasome Activity in the Plasma as a Novel Biomarker in Mild Cognitive Impairment with Chronic Tinnitus September 11, 2020
Mechanisms Underlying Enhancement of Spontaneous Glutamate Release by Group I mGluRs at a Central Auditory Synapse September 9, 2020
Transcranial direct current stimulation improves tinnitus perception and modulates cortical electrical activity in patients with tinnitus: A randomized clinical trial August 28, 2020
Loud noise exposure differentially affects subpopulations of auditory cortex pyramidal cells [Preprint] August 25, 2020

Clinical Trials

Action of Intra-auricular Topical Lidocaine on Tinnitus February 3, 2023
Evaluation of Auditory Mirror-therapy for Tinnitus February 2, 2023
Assessment of Bimodal Stimulation Device [Lenire] Compliance and Satisfaction in Individuals With Tinnitus September 14, 2022
Treatment Evaluation of Neuromodulation for Tinnitus – Stage A3 February 7, 2022
A Pilot Evaluation of the Effect of the Erchonia® HLS™ for the Relief of Tinnitus Symptoms October 25, 2021
High Dose Oxytocin Nasal Spray for Treatment of Tinnitus July 12, 2021
OTO-313 in Subjects With Unilateral Subjective Tinnitus June 11, 2021
Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus May 25, 2021
Evaluation of the OtoBand as a Treatment to Reduce the Perceived Loudness of Tinnitus May 10, 2021
Cochlear Promontory Stimulation for Treatment of Tinnitus April 30, 2021
An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus April 29, 2021
Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss [Diagnostic] April 28, 2021
Effect of Highly Bioavailable Curcumin on Subjective Tinnitus March 16, 2021
Effectiveness of Intratympanic Dexamethasone With Lignocaine for Alleviation of Tinnitus March 15, 2021
Daily Bitemporal Low-frequency Transcranial Random Noise Stimulation in Tinnitus (tRNS2-tin) January 20, 2021
Acoustic and Electrical Stimulation for the Treatment of Tinnitus January 14, 2021
Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts November 13, 2020
Investigating Accelerated Learning in Tinnitus Participants Implanted With Vagus Nerve Stimulation [Suspended] November 4, 2020
Novel Tinnitus Implant System for the Treatment of Chronic Severe Tinnitus October 19, 2020
Transcranial Electrical and Acoustic Stimulation for Tinnitus September 16, 2020
ICCAC-ToNF EEG Neurofeedback Training & Tinnitus September 4, 2020
MRI Study of Noninvasive Transcranial Electrical Stimulation in Tinnitus August 31, 2020
OTO-313 in Subjects With Subjective Tinnitus [Completed] June 17, 2020
Treatment of Tinnitus With Migraine Medications May 27, 2020
Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus May 22, 2020
Deep Brain Stimulation for Tinnitus March 23, 2020
Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS) March 5, 2020
Phase 2a Efficacy Study of FX-322 in Adults With Stable Sensorineural Hearing Loss January 29, 2020
Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation [Terminated] December 19, 2019
Novel Tinnitus Implant System for the Treatment of Chronic Severe Tinnitus November 19, 2019
Effects of Sound Stimulation, Somatosensory Stimulation, Vestibular Stimulation and the Combinations on Tinnitus Loudness and Tinnitus Related Distress in Patients October 8, 2019
A Phase-II Clinical Trial on the Effectiveness of Antioxidant Supplementation in Idiopathic Tinnitus Patients [Completed] September 26, 2019
Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral Tinnitus May 30, 2019
Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation May 21, 2019
Treatment Evaluation of Neuromodulation for Tinnitus – Stage A2 (TENT-A2) [Neuromod] April 30, 2019
Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus [Withdrawn (Lack of funding and personnel)] April 29, 2019
FX-322 in Sensorineural Hearing Loss [Completed] April 10, 2019
Experimental Tinnitus Treatment With Transcranial Magnetic Stimulation February 6, 2019
Treatment Evaluation of Neuromodulation for Tinnitus (TENT-A) [Neuromod] January 1, 2019
Effects of Kinesio Taping in Patients With Somatosensory Tinnitus December 20, 2018
Regulating Homeostatic Plasticity and the Physiological Response to rTMS November 28, 2018
Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts [Susan Shore] November 12, 2018
The Study of Wuling Capsule in Treatment Chronic Tinnitus September 18, 2018

Projects

Cell-based approach for increasing central auditory inhibition May 1, 2021
Targeting Multiple Signaling Pathways for Tinnitus Prevention and Treatment July 1, 2020
Identification of inputs to unipolar brush cells and their roles in multisensory processing January 1, 2020

New and Upcoming Treatments for Tinnitus