Tinnitus Treatment Report

News

• Gateway Biotechnology Adds Three New Tinnitus Drugs to Pipeline: GW-TT2, GW-TT5, GW-TT23 September 20, 2023
• Sage Therapeutics Starting Phase 2 Study of SAGE-547 (6-hour infusion drug) for Treating Tinnitus December 9, 2022
• New Anti-Tinnitus Drugs May Target Vasoactive Intestinal Peptide (VIP) Excitability November 29, 2022
• BREAKING: Otonomy Completes Phase 2 Clinical Trial of OTO-313 for Tinnitus… July 9, 2022
• NEOMED Researchers Explore Chemogenetic Modulators for Treatment of Chronic Tinnitus June 13, 2022
• RespireRx Pharmaceuticals Highlights Potential Use of GABAkine Neuromodulators for Treatment of Tinnitus May 16, 2022
• Neuromod Initiates Stage 3 (TENT-A3) Clinical Trial of Lenire Device for Tinnitus Treatment February 7, 2022
• D-serine and its signaling pathway may represent a new druggable target for treating tinnitus January 15, 2022
• Phase 3 Clinical Trial of OTO-313 for Tinnitus Expected to Start in First Half of 2023 January 6, 2022
• Otonomy Announces Publication of Phase 1/2 Trial Results Showing Tinnitus Improvement in Patients Receiving OTO-313 October 12, 2021
• Susan Shore’s New “Auricle Device” for Tinnitus Is Almost Ready for Commercial Release… September 7, 2021
• July 2021 update on Cognosetta’s tinnitus drug: CS0022 July 21, 2021
• Anti-Tinnitus Effects of “Prism Adaptation” Glasses: Researchers in France to Begin Major Study Next Month (August 2021) July 9, 2021
• Impact of Sazetidine-A and Similar Nicotinic Drugs on Tinnitus June 23, 2021
• Sulodexide Anticoagulant Therapy for Chronic Tinnitus: Phase 3 Clinical Trials — When? June 18, 2021
• Thanos Tzounopoulos explains the current state of tinnitus drug development research (and the crucial missing piece) June 3, 2021
• Brian Fargo, inXile founder, gives $1 million to advance UCI research for tinnitus treatment May 19, 2021
• Efficacy of donepezil in patients with chronic tinnitus May 17, 2021
• Ketamine + HD-tIPNS for tinnitus: Professor Dirk De Ridder investigates effects of new “drug/device combo” therapy May 12, 2021
• University of Granada researchers identify genes linked to severe tinnitus April 29, 2021
• Researchers evaluating the effects of bitter almond oil and cinnarizine on chronic tinnitus severity April 26, 2021
• Otonomy Now Recruiting Participants for Phase 2 Study of OTO-313 in Tinnitus [Update: New Locations Added] April 11, 2021
• Otonomy Initiates Phase 2 Clinical Trial of OTO-313 in Tinnitus March 25, 2021
• MISSING: Day-90 Study Results on Impact of FX-322 on Tinnitus… March 25, 2021
• American Tinnitus Association Seeking Tinnitus Research Proposals… “that may contribute to scientific understanding of tinnitus, breakthroughs in treatments, and possible cures” March 12, 2021
• Otolith Labs Initiates Clinical Trial of OtoBand Device as a Treatment to Reduce Perceived Loudness of Tinnitus March 8, 2021
• Frequency Therapeutics Announces Publication of Phase 1/2 Data Showing Hearing Improvements in Patients Receiving FX-322 February 22, 2021
• Otonomy Shifts Focus to Hearing Loss and Tinnitus [OTO-313] After Meniere’s Phase III Failure February 22, 2021
• Novel Tinnitus Drug CS0022 Reduces Chronic Tinnitus in Preclinical Study February 8, 2021
• Discovery of a New Type of Inhibitory Neuron [L-stellate cells] Holds Clues About Tinnitus February 4, 2021
• BREAKTHROUGH: NAC/HPN-07, also known as the Hough Ear Institute’s NHPN-1010, significantly reduced the incidence of tinnitus, study finds… January 7, 2021
• American Tinnitus Association Receives $2.7 Million Donation – Money Will Help Fund Strategic Long-Term Tinnitus Research December 26, 2020
• Hubert Lim on Neuromodulation and Research Behind the Lenire Device for Tinnitus [PDF] December 14, 2020
• What can biobanks bring to hearing, and in particular to tinnitus? December 4, 2020
• British Tinnitus Association awards £125k grant for research that could predict who will develop tinnitus December 4, 2020
• Otonomy expects to start Phase 2 trial of OTO-313 in tinnitus in first quarter of 2021 November 30, 2020
• In Case You Missed It: Tinnitus Hub Director Hazel Goedhart gives us the cold, hard, unbiased facts about Lenire… November 24, 2020
• Researchers Develop New Technology to Objectively Measure Tinnitus November 19, 2020
• Technology lets clinicians objectively detect tinnitus for first time November 18, 2020
• New FX-322 clinical trial for severe hearing loss includes tinnitus assessment as secondary outcome measure November 16, 2020
• The role of prediction and gain in tinnitus November 2, 2020
• Frequency Therapeutics Will Report FX-322 Phase 2a Study Data in Late Q1 2021 October 29, 2020
• Neuromod Successfully Closes $12.4 Million Series B Financing for Tinnitus Treatment Device Lenire® October 20, 2020
• Auckland University researchers trialing MDMA as tinnitus cure October 17, 2020
• Heavy metals could play important role in development of tinnitus, study finds October 12, 2020
• New Treatment Alleviates Ringing in the Ears: A noninvasive device [Lenire] designed to rewire brain circuits reduced symptoms of tinnitus in a large clinical trial October 7, 2020
• Is tinnitus all in the genes? September 25, 2020
• How much will FX-322 cost? David Lucchino, Frequency Therapeutics CEO, responds… September 24, 2020
• Frequency Therapeutics Completes Enrollment of FX-322 Phase 2a Study for Sensorineural Hearing Loss September 22, 2020
• Proposed “Multi-Cause Framework” of Tinnitus May Speed Up Development of New Therapies September 17, 2020
• Possible tinnitus gene found: Genetic variation in RCOR1 is associated with tinnitus September 14, 2020
• Frequency Therapeutics Presents Results Demonstrating Sustained Improvement in Hearing Loss Patients Treated with FX-322 September 13, 2020
• First report showing benefit of spinal cord stimulation in tinnitus September 12, 2020
• Dr. Will Sedley discusses role of “predictive brain processing” in tinnitus – via Tinnitus Talk [PDF] September 7, 2020
• British Tinnitus Association’s 2020 Tinnitus Conference Goes Virtual: October 5 – 9 August 27, 2020
• Not-yet-published tinnitus research preprints… August 26, 2020
• FX-322 phase 2a study results anticipated in second quarter of 2021… August 12, 2020
• Carl LeBel (Chief Development Officer at Frequency Therapeutics) talks FX-322 in latest interview – via Tinnitus Talk [PDF] July 25, 2020
• Update on new tinnitus drug (GW-201) from NEOMED researcher Jianxin Bao and Gateway Biotechnology July 20, 2020
• NEOMED researcher receives federal grant for first human tinnitus treatment July 15, 2020
• NIH Funds NEOMED Tinnitus Researcher July 8, 2020
• Otonomy Reports Positive Top-Line Results from Phase 1/2 Clinical Trial of OTO-313 in Patients with Tinnitus July 6, 2020
• Otonomy Provides Update on Clinical Trials: Results from Phase 1/2 trial of OTO-313 for tinnitus expected in July 2020 June 15, 2020
• Congressman Announces National Institute on Deafness and Other Communications Disorders Grant for Tinnitus Prevention and Treatment June 11, 2020
• Frequency Therapeutics Shares Clinical Data From Exploratory Study Confirming Delivery of FX-322 to the Cochlea – Top-Line Results Show Consistent Drug Entry in All Patients May 14, 2020
• FAU researchers use computer-based ‘stochastic resonance’ model of tinnitus as a basis for developing new treatment strategies May 13, 2020
• Updated list of hearing loss treatment news and research available at HearingLossTreatmentReport.com May 1, 2020
• Tinnitus Research Spotlight: A unified explanation of tinnitus development based on the Stochastic Resonance (SR) model of auditory perception April 21, 2020
• NO COVID-19 SLOWDOWN: Frequency Therapeutics Adds Another Recruitment Site for FX-322 Phase 2a Study (HearingLossTreatmentReport.com) April 14, 2020
• Treatments for tinnitus may need to enhance cortical plasticity rather than reverse it… March 24, 2020
• Study findings demonstrate that Lenire (Neuromod) for tinnitus “provides safe, fast-acting (within 6 weeks) and reproducible therapeutic effects that can last at least 12 months.” March 11, 2020
• Toward Tinnitus Subtyping: or Finding a Specific Personalized Treatment for Each Patient February 15, 2020
• Why Tinnitus Needs Citizen Science: A Researcher’s Perspective February 8, 2020
• Developing effective treatments or even a cure for tinnitus February 3, 2020
• Resaphene Suisse AG: Charité Ethics Committee in Berlin Approves Study on Tinniwell Tinnitus Therapy January 21, 2020
• Cognosetta, Inc receives funding from NIH to test a novel therapeutic for treating tinnitus (BMS-191011) January 14, 2020
• New ‘fast-track’ system for tinnitus and hearing loss January 10, 2020
• Auris Medical Receives “Intention to Grant” notice from European Patent Office for New Oral NKCC1 inhibitor Treatment for Tinnitus January 10, 2020
• Zilentin: Auris Medical Announces Formation of New Subsidiary for Development Projects in Tinnitus and Hearing Loss December 30, 2019
• American Tinnitus Association and British Tinnitus Association Partner to Spark Innovations in Tinnitus Treatments and Advance Global Discussion About Potential Tinnitus Breakthroughs December 10, 2019
• Proof of concept to support MDMA as a potential treatment for tinnitus? December 10, 2019
• Frequency Therapeutics CEO: “We have opened all U.S. sites for our Phase 2a study of FX-322 and remain on track to report top-line data in the second half of next year.” November 18, 2019
• RESEARCH: Experimental procedure enables suppression of auditory cortex alpha activity in patients with chronic tinnitus November 17, 2019
• Neuromodulation for Tinnitus Relief: Interview with Neuromod Devices CEO Dr. Ross O’Neill October 24, 2019
• The cortisol awakening response: could this be an effective measure of tinnitus distress? October 23, 2019
• FDA Grants FX-322 Fast Track Designation October 10, 2019
• Frequency Therapeutics Begins Recruiting for Phase 2 Study of FX-322 in Patients with Sensorineural Hearing Loss October 9, 2019
• VIDEO: Susan Shore on Bimodal Stimulation for Tinnitus – #TRI2019 (via TinnitusHub) October 8, 2019
• Neuromod (Lenire) Clinical Trial Data “Locked” Until Fall 2020? Study Results “Delayed” Until 2021? October 3, 2019
• Neuromod Successfully Closes €8 Million Capital Raise: proceeds will be used to accelerate ongoing commercialization of Lenire® tinnitus treatment device September 26, 2019
• A Breakthrough in Understanding Tinnitus: The Entire Hearing System Studied September 25, 2019
• Possible Link Between Marijuana Use, Tinnitus September 16, 2019
• Auris Medical Receives FDA and EMA Guidance for Keyzilen® (AM-101) Late-Stage Clinical Development Program September 13, 2019
• ABSTRACT: Phase 1/2 Hearing Loss Trial of Intratympanic FX322, a Progenitor Cell Activator September 11, 2019
• BREAKING: FX-322 Clinical Trial Results… September 6, 2019
• Auris Medical Announces Formation of Scientific Advisory Board for Tinnitus Programs August 26, 2019
• UA Rodent Study Identifies Possible Tinnitus Treatment Target August 26, 2019
• Brain Inflammation Identified as Potential Target to Treat Tinnitus August 20, 2019
• Tinnitus Cure Map from the British Tinnitus Association [image] August 6, 2019
• Frequency Therapeutics prepares to advance first-in-class drug candidate FX-322 into Phase 2a study… July 23, 2019

Research

• The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus July 7, 2023
• A randomized, double-blind, placebo-controlled phase 2 study of intratympanic OTO-313 in patients with moderate to severe subjective tinnitus June 21, 2023
• Effects of transcutaneous auricular vagus nerve stimulation paired with tones on electrophysiological markers of auditory perception June 17, 2023
• Targeting the Limbic System: Insights into Its Involvement in Tinnitus June 7, 2023
• The effectiveness of two types of low-level laser therapy in patients with persistent tinnitus June 4, 2023
• Reversing Synchronized Brain Circuits Using Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts: A Randomized Clinical Trial June 2, 2023
• Endocannabinoid system components as potential neuroimmune therapeutic targets in tinnitus May 24, 2023
• Desensitizing nicotinic agents normalize tinnitus-related inhibitory dysfunction in the auditory cortex and ameliorate behavioral evidence of tinnitus May 24, 2023
• In Silico Study in MPO and Molecular Docking of the Synthetic Drynaran Analogues Against the Chronic Tinnitus: Modulation of the M1 Muscarinic Acetylcholine Receptor April 20, 2023
• Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy March 27, 2023
• Association of Plasma Metabolomic Biomarkers With Persistent Tinnitus March 16, 2023
• Extreme meteorological conditions are associated with tinnitus-related EV rates March 1, 2023
• Efficacy and safety of acupuncture and moxibustion for primary tinnitus: A systematic review and meta-analysis February 26, 2023
• Auditory Mirror Therapy for Tinnitus: A Pilot Study November 18, 2022
• Therapeutic effects of Rosa Canina, Urtica Dioica and Tanacetum Vulgare Herbal Combination in Treatment of Tinnitus Symptoms; A Double-blind Randomized Clinical Trial October 21, 2022
• Using prism adaptation to alleviate perception of unilateral tinnitus: A case study October 1, 2022
• Cell-type-specific roles of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage September 15, 2022
• Different bimodal neuromodulation settings reduce tinnitus symptoms in a large randomized trial June 30, 2022
• Decreasing dorsal cochlear nucleus activity ameliorates noise-induced tinnitus perception in mice May 12, 2022
• Can GABAkines Quiet the Noise? The GABAA Receptor Neurobiology and Pharmacology of Tinnitus April 30, 2022
• The Quantum Tunneling of Ions Model Can Explain the Pathophysiology of Tinnitus March 23, 2022
• The Road Traveled and Journey Ahead for the Genetics and Genomics of Tinnitus February 15, 2022
• Electric hearing and tinnitus suppression by noninvasive ear stimulation January 5, 2022
• Potential inflammatory biomarkers for tinnitus in platelets and leukocytes January 3, 2022
• Intratympanic Administration of OTO-313 Reduces Tinnitus in Patients With Moderate to Severe, Persistent Tinnitus: A Phase 1/2 Study October 8, 2021
• Striatal networks for tinnitus treatment targeting October 5, 2021
• Effects of two inhibitors of metabolic glutamate receptor 5 on mice with tinnitus September 21, 2021
• The role of vitamin D in subjective tinnitus: findings suggest vitamin D level correlates with tinnitus impact August 18, 2021
• Efficacy of pharmacologic treatment in tinnitus patients without specific or treatable origin August 13, 2021
• Simulated transient hearing loss improves auditory sensitivity July 20, 2021
• Review of Pharmacotherapy for Tinnitus June 21, 2021
• The Neuroscience and the Treatment of Tinnitus: what is the crucial missing piece in tinnitus research? May 28, 2021
• Insufficient Evidence: Gabapentin’s Efficacy in Tinnitus Treatment – A Systematic Review May 26, 2021
• Role of microRNA‑375‑3p‑mediated regulation in tinnitus development May 21, 2021
• Cochlear nucleus small cells use olivocochlear collaterals to encode sounds in noise [Preprint] [Susan Shore] May 21, 2021
• Auditory thalamus dysfunction and pathophysiology in tinnitus: a predictive network hypothesis May 2, 2021
• The bewitched ear: State of the art genomics research on tinnitus April 24, 2021
• Activity of CaMKIIa+ dorsal cochlear nucleus neurons are crucial for tinnitus perception but not for tinnitus induction [Preprint] April 8, 2021
• Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study April 1, 2021
• What’s the Buzz? The Neuroscience and the Treatment of Tinnitus [Thanos Tzounopoulos] March 26, 2021
• Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank March 19, 2021
• Effectiveness of photobiomodulation in the management of tinnitus remains debatable: A systematic review March 5, 2021
• Increased Serum Lipid Levels in Patients with Subjective Tinnitus February 21, 2021
• Development of Ebselen for the Treatment of Sensorineural Hearing Loss and Tinnitus February 19, 2021
• The progression of chronic tinnitus over the years February 18, 2021
• Pharmacological Evaluation of Drugs in Animal Models of Tinnitus February 16, 2021
• Transient Delivery of a KCNQ2/3-Specific Channel Activator [RL-81] 1 Week After Noise Trauma Mitigates Noise-Induced Tinnitus February 11, 2021
• Using cortical neuron markers to target cells in the dorsal cochlear nucleus: new means for treatment of bothersome tinnitus? February 9, 2021
• Glucose Control Has an Impact on Cerebral Blood Flow Alterations in Chronic Tinnitus Patients February 4, 2021
• Altering activity in the peripheral nerve may be a viable target for early pharmaceutical intervention in forms of tinnitus originating in the cochlea February 3, 2021
• Spontaneous firing patterns in the medial geniculate nucleus in a guinea pig model of tinnitus January 30, 2021
• The BDNF Val66 Met polymorphism regulates vulnerability to chronic stress and phantom perception January 22, 2021
• Metabolic changes in the brain and blood of rats following acoustic trauma, tinnitus and hyperacusis January 19, 2021
• Review: Neural Mechanisms of Tinnitus and Hyperacusis January 19, 2021
• Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus January 15, 2021
• Efficacy of fluoxetine vs. fluoxetine plus alprazolam in treatment of chronic tinnitus: No reduction in Tinnitus Severity Index (TSI) January 15, 2021
• Towards personalized rTMS in tinnitus: reliability of individualized stimulation protocols in behavioral and electrophysiological responses [Preprint] January 13, 2021
• Tinnitus-like “hallucinations” elicited by sensory deprivation in an entropy maximization recurrent neural network [Preprint] January 11, 2021
• Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus January 7, 2021
• Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma January 5, 2021
• Prediction of Acoustic Residual Inhibition of Tinnitus Using a Brain-Inspired Spiking Neural Network Model January 5, 2021
• Low-Level Laser Therapy as a Therapeutic Strategy for Patients With Tinnitus: Not Yet Proven December 29, 2020
• ATP-sensitive K+ channels control the spontaneous firing of a glycinergic interneuron in the auditory brainstem December 28, 2020
• Subcortical and cortical responses are enlarged in tinnitus patients with hyperacusis compared to those without hyperacusis December 24, 2020
• Systematic review and meta-analysis of late auditory evoked potentials as a candidate biomarker in the assessment of tinnitus December 17, 2020
• Neurophysiological correlates of residual inhibition in tinnitus: Hints for trait-like EEG power spectra December 16, 2020
• Gray matter declines with age and hearing loss, but is partially maintained in tinnitus December 11, 2020
• Purinergic signaling controls spontaneous activity in the auditory system throughout early development December 10, 2020
• A Review and a Framework of Variables for Defining and Characterizing Tinnitus Subphenotypes December 4, 2020
• A tale of two tinnituses: Does hearing status influence central tinnitus localization? December 3, 2020
• Efficacy of Low-Level Laser Therapy for Tinnitus: A Systematic Review with Meta-Analysis and Trial Sequential Analysis December 2, 2020
• Tinnitus and auditory cortex: using adapted functional near-infrared spectroscopy to measure resting-state functional connectivity November 27, 2020
• Association Between Tinnitus Pitch and Consonant Recognition in Noise November 25, 2020
• Switching Tinnitus-On: Maps and source localization of spontaneous EEG November 23, 2020
• Cannabinoids, Inner Ear, Hearing, and Tinnitus: A Neuroimmunological Perspective November 23, 2020
• A Gradient of Sharpening Effects by Perceptual Prior across the Human Cortical Hierarchy November 18, 2020
• Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning November 18, 2020
• Tinnitus impairs segregation of competing speech in normal-hearing listeners November 16, 2020
• Increased central gain caused by reduced auditory input is a major mechanism of tinnitus but may originate from other pathophysiologic factors rather than from cochlear synaptopathy November 10, 2020
• Tinnitus Symptoms Improve With Sound and Tongue Stimulation November 10, 2020
• What Makes Tinnitus Loud? November 8, 2020
• Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem November 5, 2020
• Effect of age on the gap-prepulse inhibition of the cortical N1-P2 complex in humans as a step towards an objective measure of tinnitus November 5, 2020
• Does the tinnitus pitch correlate with the frequency of hearing loss? November 4, 2020
• Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus November 3, 2020
• A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response October 30, 2020
• Dietary Factors and Tinnitus among Adolescents October 27, 2020
• The Prevalence of Different Types of Headache in Patients with Subjective Tinnitus and Its Influence on Tinnitus Parameters: A Prospective Clinical Study October 24, 2020
• Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus October 13, 2020
• Noise Induced Hearing Loss and Tinnitus-New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention October 13, 2020
• The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus October 9, 2020
• Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study October 7, 2020
• High Definition transcranial Direct Current Stimulation (HD-tDCS) for chronic tinnitus: outcomes from a prospective longitudinal large cohort study [Preprint] October 2, 2020
• Phenotyping chronic tinnitus patients using self-report questionnaire data: cluster analysis and visual comparison October 2, 2020
• How can sound generating devices support coping with tinnitus? October 1, 2020
• A New Buzz for Tinnitus—It’s in the Genes! September 24, 2020
• Novel Genetic Risk Loci Associated with Tinnitus and Causal Inference with Hearing Loss and Neuropsychiatric Disorders and Traits September 24, 2020
• Individualized Treatment of Tinnitus during Sleep Using Stimulation of the Auditory and Limbic Systems September 23, 2020
• Using cortical neuron markers to target cells in the dorsal cochlear nucleus: novel tools for studying tinnitus mechanisms [Preprint] September 20, 2020
• Perceptual Dimensions Underlying Tinnitus-Like Sounds September 18, 2020

• Dual-site rTMS is More Effective than Single-site rTMS in Tinnitus Patients: A Blinded Randomized Controlled Trial September 17, 2020
• The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants September 16, 2020
• Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study [Preprint] September 15, 2020
• Glutamatergic modulation of auditory cortex connectivity with attentional brain networks in unpredictable perceptual environment September 14, 2020
• Genetic variation in RCOR1 is associated with tinnitus in UK Biobank [Preprint] September 13, 2020
• From Acute to Chronic Tinnitus: Pilot Data on Predictors and Progression September 11, 2020
• Proteasome Activity in the Plasma as a Novel Biomarker in Mild Cognitive Impairment with Chronic Tinnitus September 11, 2020
• Mechanisms Underlying Enhancement of Spontaneous Glutamate Release by Group I mGluRs at a Central Auditory Synapse September 9, 2020
• Transcranial direct current stimulation improves tinnitus perception and modulates cortical electrical activity in patients with tinnitus: A randomized clinical trial August 28, 2020
• Loud noise exposure differentially affects subpopulations of auditory cortex pyramidal cells [Preprint] August 25, 2020
• Tinnitus severity significantly worse in patients with hearing loss than patients with normal hearing August 13, 2020
• Acupuncture for tinnitus: level of evidence insufficient to draw any definitive conclusions August 10, 2020
• Uncovering the Contribution of Enhanced Central Gain and Altered Cortical Oscillations to Tinnitus Generation August 9, 2020
• Susceptibility to Residual Inhibition is Associated with Hearing Loss and Tinnitus Chronicity [Preprint] August 6, 2020
• Single nucleotide polymorphisms in tinnitus patients exhibiting severe distress: severity of tinnitus is associated with genetic background August 3, 2020
• Analysis of cerebellum with magnetic resonance 3D T1 sequence in individuals with chronic subjective tinnitus August 3, 2020
• Association between Hyperacusis and Tinnitus July 28, 2020
• The Efficacy of Intratympanic Steroid Injection (Dexamethasone) in Tinnitus Cases Unresponsive to Medical Treatment July 28, 2020
• Analysis of Auditory Brainstem Response Change, according to Tinnitus Duration, in Patients with Tinnitus with Normal Hearing July 28, 2020
• Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus July 26, 2020
• Loss of Cochlear Ribbon Synapse Is a Critical Contributor to Chronic Salicylate Sodium Treatment-Induced Tinnitus without Change Hearing Threshold July 25, 2020
• Genetic Inheritance and Its Contribution to Tinnitus July 24, 2020
• A Case Report of High Cervical Spinal Cord Stimulation for Chronic Otalgia and Tinnitus July 23, 2020
• Increasing endogenous activity of NMDARs on GABAergic neurons prevents noise-induced tinnitus July 20, 2020
• Nitric oxide increases gain within the ventral cochlear nucleus of guinea pigs with tinnitus July 19, 2020
• Potential Role of Noninvasive Brain Stimulation Interventions (NIBS) in Tinnitus Management July 9, 2020
• The sound-sensitive tinnitus index: Psychometric properties of a scale to assess the impact of tinnitus exacerbated by sound July 9, 2020
• Fluctuations in Subjective Tinnitus Ratings Over Time: Implications for Clinical Research July 3, 2020
• Long-lasting total remission of tinnitus: A systematic collection of cases July 2, 2020
• Total remission or persistence of tinnitus and decreased sound level tolerance in adolescents with normal audiograms: A follow-up study July 2, 2020
• Evidence of Reorganization of Brain White Matter in Persistent Idiopathic Tinnitus Patients Without Hearing Loss Suggests Close Relationship Between Tinnitus and Limbic System July 2, 2020
• Dorsomedial Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation (rTMS) for Tinnitus: Results of a Blinded, Randomized, Sham-Controlled Study July 2, 2020
• Auditory Neural Plasticity in Tinnitus Mechanisms and Management July 1, 2020
• Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss June 30, 2020
• Non-Invasive Neuromodulation for Tinnitus June 25, 2020
• Impact of Acamprosate on Chronic Tinnitus: a subjective relief of tinnitus and some degree of electrophysiological improvement June 5, 2020
• High mean platelet volume and neutrophil to lymphocyte ratio values are associated with idiopathic tinnitus, suggesting the role of vascular pathologies in etiology of tinnitus June 4, 2020
• Improved pure tone sensitivity after simulated hearing loss [Preprint] May 31, 2020
• Transcutaneous Electrical Nerve Stimulation (TENS) for Treatment of Tinnitus: a safe and feasible intervention option May 28, 2020
• Altered Topological Patterns of Gray Matter Networks in Tinnitus: A Graph-Theoretical-Based Study May 27, 2020
• Associations Between Subjective Tinnitus and Cognitive Performance: Systematic Review and Meta-Analyses May 21, 2020
• Binaural Interaction in Tinnitus Patients: the presence of binaural processing deficits in tinnitus patients May 13, 2020
• Tinnitus associated with benzodiazepine withdrawal syndrome: a rare but debilitating and long-term risk May 7, 2020
• Avenue for Future Tinnitus Treatments May 4, 2020
• Heritability and Genetics Contribution to Tinnitus April 22, 2020
• Current Device-based Clinical Treatments for Tinnitus April 22, 2020
• Regulation of auditory plasticity during critical periods and following hearing loss: associations with tinnitus April 20, 2020
• Microstate in resting state: an EEG indicator of tinnitus? April 17, 2020
• The Stochastic Resonance model of auditory perception: A unified explanation of tinnitus development, Zwicker tone illusion, and residual inhibition March 29, 2020
• Cortical Tonotopic Map Changes in Humans are Larger in Hearing Loss than in additional Tinnitus March 19, 2020
• Investigating functional changes in the brain to intermittently induced auditory illusions and its relevance to chronic tinnitus March 10, 2020
• Relationship Between Diet, Tinnitus, and Hearing Difficulties March 1, 2020
• Effects of Vibrant Soundbridge (VSB) on Tinnitus Accompanied by Sensorineural Hearing Loss February 4, 2020
• Beyond Hearing Loss: Does Tinnitus Cause Cognitive Impairment? February 1, 2020
• Plasticity in Limbic Regions at Early Time Points in Experimental Models of Tinnitus January 24, 2020
• A mouse model for temporary and persistent tinnitus using the gap startle paradigm January 22, 2020
• Is there an association between the parameters of arterial stiffness and tinnitus? January 13, 2020
• A 7 Tesla fMRI Investigation of Human Tinnitus Percept in Cortical and Subcortical Auditory Areas January 11, 2020
• Perceptual Modeling of Tinnitus Pitch and Loudness January 8, 2020
• Single dose of hallucinogenic compound 5-MeO-DMT can be effective in treating tinnitus-related anxiety January 8, 2020
• Cognitive behavioural therapy for tinnitus: uncertainty remains due to concerns about quality of evidence and an absence of evidence at 6 or 12 months follow-up January 8, 2020
• A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity January 6, 2020
• Amplitude Modulated Noise for Tinnitus Suppression in Tonal and Noise-Like Tinnitus January 6, 2020
• The effect of fibromyalgia treatment on tinnitus January 3, 2020
• Altered functional connectivity of the thalamus in tinnitus patients is correlated with symptom alleviation after sound therapy January 3, 2020
• Within-Subject Analysis of Auditory Brain Stem Responses in Adults With Unilateral Tinnitus December 26, 2019
• Ginkgo biloba for tinnitus – Cochrane Database of Systematic Reviews December 23, 2019
• In support of a striatal gating model of tinnitus: new biomarkers to monitor and target specific brain areas for neuromodulation therapies December 20, 2019
• Abnormal Spontaneous Neural Activity of the Central Auditory System Changes the Functional Connectivity in the Tinnitus Brain December 20, 2019
• Enhancement of VGLUT3 expression in cochlear inner hair cells may contribute to the pathogenesis of tinnitus December 19, 2019
• Analysis of the audiological characteristics and comorbidity in patients with chronic tinnitus December 19, 2019
• Morphological Neuroimaging Biomarkers for Tinnitus: Evidence Obtained by Applying Machine Learning December 13, 2019
• The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial December 12, 2019
• Treatment Outcome of Auditory and Frontal Dual-Site rTMS in Tinnitus Patients: A beneficial effect of rTMS on tinnitus suppression December 12, 2019
• Intensity Mismatch Asymmetry (IMA): a new tinnitus biomarker based on a prediction resetting model of tinnitus generation December 11, 2019
• A proof-of-principle study of the short-term effects of MDMA (3,4-methylenedioxymethamphetamine) on tinnitus and neural connectivity December 7, 2019
• Chronic Tinnitus Exhibits Bidirectional Functional Dysconnectivity in Frontostriatal Circuit December 6, 2019
• Blast Trauma-Induced Tinnitus vs. Noise Trauma-Induced Tinnitus: Similarities and Differences November 27, 2019
• Medicines discovery for auditory disorders (including potential treatments for tinnitus): Challenges for industry November 27, 2019
• Real-time monitoring and regulating auditory cortex alpha activity in patients with chronic tinnitus November 14, 2019
• Tinnitus and event related potentials: a systematic review November 4, 2019
• Maladaptive alterations of resting state cortical network in Tinnitus October 29, 2019
• The effect of transcutaneous electrical nerve stimulation (TENS) on chronic subjective tinnitus October 29, 2019
• Missed Hearing Loss in Tinnitus Patients With Normal Audiograms October 17, 2019
• Noninvasive Bimodal Neuromodulation for the Treatment of Tinnitus: Protocol for a Second Large-Scale Double-Blind Randomized Clinical Trial to Optimize Stimulation Parameters September 27, 2019
• Efficacy and safety of bilateral caudate nucleus deep brain stimulation (DBS) for treatment-resistant tinnitus September 24, 2019
• Tinnitus disrupts the functioning of auditory working memory September 21, 2019
• Hidden hearing loss and tinnitus: utility of the high-definition audiograms in diagnosis September 19, 2019
• Invasive Neuromodulation as a Treatment for Tinnitus: A Systematic Review September 16, 2019
• Auditory Brainstem Response in Patients With Tinnitus Associated With Vitamin B12 Deficiency September 15, 2019
• A Prospective Study to Evaluate Effectiveness of a Tinnitus Relief Device (TRx) in a Clinical Setup September 4, 2019
• Outcomes of Triple-Combination Therapy for Chronic Tinnitus September 1, 2019
• Memantine Attenuates Salicylate-induced Tinnitus Possibly by Reducing NR2B Expression in Auditory Cortex of Rat August 31, 2019
• Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus August 14, 2019
• Why Is There No Cure for Tinnitus? Current Obstacles and the New Roadmap Toward a Cure August 6, 2019
• Sound therapy (using amplification devices and/or sound generators) for tinnitus: insufficient evidence of improvement over placebo July 30, 2019
• Toward An Exploration of Habituating to Tinnitus: Perspectives on Sensory Gating July 12, 2019
• Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies July 3, 2019
• Mechanism of acupuncture efficacy on tinnitus: acupuncture associated with improvement of cochlear blood flow via infrared thermography test June 26, 2019
• Toward Personalized Tinnitus Treatment: An Exploratory Study Based on Internet Crowdsensing June 25, 2019

Clinical Trials

• Cohort Study on Biomarkers and Clinical Treatment of Tinnitus May 23, 2023
• Action of Intra-auricular Topical Lidocaine on Tinnitus February 3, 2023
• Evaluation of Auditory Mirror-therapy for Tinnitus February 2, 2023
• Assessment of Bimodal Stimulation Device [Lenire] Compliance and Satisfaction in Individuals With Tinnitus September 14, 2022
• Treatment Evaluation of Neuromodulation for Tinnitus – Stage A3 February 7, 2022
• A Pilot Evaluation of the Effect of the Erchonia® HLS™ for the Relief of Tinnitus Symptoms October 25, 2021
• High Dose Oxytocin Nasal Spray for Treatment of Tinnitus July 12, 2021
• OTO-313 in Subjects With Unilateral Subjective Tinnitus June 11, 2021
• Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus May 25, 2021
• Evaluation of the OtoBand as a Treatment to Reduce the Perceived Loudness of Tinnitus May 10, 2021
• Cochlear Promontory Stimulation for Treatment of Tinnitus April 30, 2021
• An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus April 29, 2021
• Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss [Diagnostic] April 28, 2021
• Effect of Highly Bioavailable Curcumin on Subjective Tinnitus March 16, 2021
• Effectiveness of Intratympanic Dexamethasone With Lignocaine for Alleviation of Tinnitus March 15, 2021
• Daily Bitemporal Low-frequency Transcranial Random Noise Stimulation in Tinnitus (tRNS2-tin) January 20, 2021
• Acoustic and Electrical Stimulation for the Treatment of Tinnitus January 14, 2021
• Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts November 13, 2020
• Investigating Accelerated Learning in Tinnitus Participants Implanted With Vagus Nerve Stimulation [Suspended] November 4, 2020
• Novel Tinnitus Implant System for the Treatment of Chronic Severe Tinnitus October 19, 2020
• Transcranial Electrical and Acoustic Stimulation for Tinnitus September 16, 2020
• ICCAC-ToNF EEG Neurofeedback Training & Tinnitus September 4, 2020
• MRI Study of Noninvasive Transcranial Electrical Stimulation in Tinnitus August 31, 2020
• OTO-313 in Subjects With Subjective Tinnitus [Completed] June 17, 2020
• Treatment of Tinnitus With Migraine Medications May 27, 2020
• Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus May 22, 2020
• Deep Brain Stimulation for Tinnitus March 23, 2020
• Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS) March 5, 2020
• Phase 2a Efficacy Study of FX-322 in Adults With Stable Sensorineural Hearing Loss January 29, 2020
• Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation [Terminated] December 19, 2019
• Novel Tinnitus Implant System for the Treatment of Chronic Severe Tinnitus November 19, 2019
• Effects of Sound Stimulation, Somatosensory Stimulation, Vestibular Stimulation and the Combinations on Tinnitus Loudness and Tinnitus Related Distress in Patients October 8, 2019
• A Phase-II Clinical Trial on the Effectiveness of Antioxidant Supplementation in Idiopathic Tinnitus Patients [Completed] September 26, 2019
• Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral Tinnitus May 30, 2019
• Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation May 21, 2019
• Treatment Evaluation of Neuromodulation for Tinnitus – Stage A2 (TENT-A2) [Neuromod] April 30, 2019
• Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus [Withdrawn (Lack of funding and personnel)] April 29, 2019
• FX-322 in Sensorineural Hearing Loss [Completed] April 10, 2019
• Experimental Tinnitus Treatment With Transcranial Magnetic Stimulation February 6, 2019
• Treatment Evaluation of Neuromodulation for Tinnitus (TENT-A) [Neuromod] January 1, 2019
• Effects of Kinesio Taping in Patients With Somatosensory Tinnitus December 20, 2018
• Regulating Homeostatic Plasticity and the Physiological Response to rTMS November 28, 2018
• Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts [Susan Shore] November 12, 2018
• The Study of Wuling Capsule in Treatment Chronic Tinnitus September 18, 2018

Projects

• Cell-based approach for increasing central auditory inhibition May 1, 2021
• Targeting Multiple Signaling Pathways for Tinnitus Prevention and Treatment July 1, 2020
• Identification of inputs to unipolar brush cells and their roles in multisensory processing January 1, 2020

Discussion

• Tinnitus Talk Support Forum
• r/tinnitusresearch – Reddit
• Hearing Science/Research and Tinnitus Support – Discord Server
• Reddit’s Tinnitus Community
• Tinnitus.de: Forums [German language]
• Tinnitus Support Message Board – Tapatalk
• Tinnitus Forum – HearingTracker
• British Tinnitus Association Forum | HealthUnlocked