This page keeps track of new/upcoming treatment options for tinnitus. What’s in development? What’s promising? What’s available soon? Find out below… Current topics include FX-322, neuromodulation, Lenire, OTO-313, mGluRs, TNF-α, cochlear promontory stimulation, stem cells, and more. Subscribe to Email Updates
Last updated:
November 27, 2019
News
- Frequency Therapeutics CEO: “We have opened all U.S. sites for our Phase 2a study of FX-322 and remain on track to report top-line data in the second half of next year.” Nov 18, 2019
- RESEARCH: Experimental procedure enables suppression of auditory cortex alpha activity in patients with chronic tinnitus Nov 17, 2019
- Neuromodulation for Tinnitus Relief: Interview with Neuromod Devices CEO Dr. Ross O’Neill Oct 24, 2019
- The cortisol awakening response: could this be an effective measure of tinnitus distress? Oct 23, 2019
- FDA Grants FX-322 Fast Track Designation Oct 10, 2019
- Frequency Therapeutics Begins Recruiting for Phase 2 Study of FX-322 in Patients with Sensorineural Hearing Loss Oct 9, 2019
- VIDEO: Susan Shore on Bimodal Stimulation for Tinnitus – #TRI2019 (via TinnitusHub) Oct 8, 2019
- Neuromod (Lenire) Clinical Trial Data “Locked” Until Fall 2020? Study Results “Delayed” Until 2021? Oct 3, 2019
- Neuromod Successfully Closes €8 Million Capital Raise: proceeds will be used to accelerate ongoing commercialization of Lenire® tinnitus treatment device Sep 26, 2019
- A Breakthrough in Understanding Tinnitus: The Entire Hearing System Studied Sep 25, 2019
- Possible Link Between Marijuana Use, Tinnitus Sep 16, 2019
- Auris Medical Receives FDA and EMA Guidance for Keyzilen® (AM-101) Late-Stage Clinical Development Program Sep 13, 2019
- ABSTRACT: Phase 1/2 Hearing Loss Trial of Intratympanic FX322, a Progenitor Cell Activator Sep 11, 2019
- BREAKING: FX-322 Clinical Trial Results… Sep 6, 2019
- Auris Medical Announces Formation of Scientific Advisory Board for Tinnitus Programs Aug 26, 2019
- UA Rodent Study Identifies Possible Tinnitus Treatment Target Aug 26, 2019
- Brain Inflammation Identified as Potential Target to Treat Tinnitus Aug 20, 2019
- TINNITUS CURE MAP: British Tinnitus Association (BTA) Releases Latest Version of “Big Picture” Roadmap To a Cure Aug 6, 2019
- Frequency Therapeutics prepares to advance first-in-class drug candidate FX-322 into Phase 2a study… Jul 23, 2019
- Otonomy Expands Recruiting Locations for Phase 1/2 Clinical Trial of OTO-313 in Patients with Subjective Tinnitus Jul 20, 2019
- The Truth About Tinnitus Habituation: Deficient Sensory Gating Could Explain Why Many Tinnitus Victims Do Not Habituate Jul 18, 2019
- Frequency Therapeutics licenses FX-322 outside U.S. to Astellas Pharma for $80M. Both companies will work on global clinical trials for the treatment and coordinate launch efforts. Jul 17, 2019
- New Treatment-Related Research from Dr. Susan Shore: Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies Jul 14, 2019
- ANNOUNCEMENT: new website for hearing loss treatment updates: HearingLossTreatmentReport.com Jul 14, 2019
- Research Roundup: 20+ field reports from the Tinnitus Research Initiative (TRI) 2019 Conference in Taipei Jul 2, 2019
- New findings support the view that tinnitus could be a proprioceptive illusion related to the middle-ear muscles Jun 27, 2019
- Susan Shore: Cochlear damage may be necessary but not sufficient to induce tinnitus Jun 26, 2019
- Drug to reduce brain inflammation cured tinnitus in mice – paving the way towards a pill for humans Jun 18, 2019
- Reducing brain inflammation could treat tinnitus and other hearing loss-related disorders Jun 18, 2019
- New breakthrough pill could cure tinnitus [sensationalized headline] Jun 18, 2019
- Sound Pharmaceuticals Completes Phase 2 Study of SPI-1005 for the Treatment of Tinnitus and Vertigo in Patients with Meniere’s Disease Jun 18, 2019
- UPDATE: Frequency Therapeutics to present newest FX-322 clinical trial results on September 17, 2019 [early] Jun 6, 2019
- What’s really going on in the world of tinnitus research? Seven insights from the #TRI2019 Conference… May 31, 2019
- New study results raise serious concerns about effectiveness of Tinnitus Retraining Therapy (TRT) May 25, 2019
- Frequency Therapeutics to present major FX-322 update on September 18, 2019 at AAO-HNSF Annual Meeting in New Orleans May 18, 2019
- Possible tinnitus remedy uncovered during ethnobotanical study of medicinal plants used in Central Macedonia, Greece May 14, 2019
- Major analysis of tinnitus patients’ hearing loss points to “stochastic resonance” (SR) as root cause of tinnitus May 14, 2019
- Neuromod Broadens Senior Leadership Team in Preparation for Global Commercialisation of Lenire™ Tinnitus Treatment May 8, 2019
- Neuromod updates anticipated study completion date of device clinical trial May 8, 2019
- First study investigating the relationship between chronic tinnitus and peripheral blood derived BDNF/ GDNF promoter methylations Apr 30, 2019
- NEUROMOD VIDEO: “New Treatment for Tinnitus Evaluated in over 500 Patients” [Dr. Hubert Lim presentation] Apr 29, 2019
- Auris Medical Provides Update on Tinnitus Drug Development Strategy Apr 25, 2019
- Phase 1/2 clinical trial of OTO-313 (single intratympanic injection) in patients with subjective tinnitus is now recruiting Apr 17, 2019
- Otonomy Initiates Phase 1/2 Clinical Trial to evaluate the therapeutic potential of OTO-313 in patients with tinnitus Apr 11, 2019
- Biotech Frequency shows early positive results for small-molecule hearing loss therapy (FX-322) Apr 9, 2019
- Frequency Therapeutics Announces Positive Phase 1/2 Data for FX-322 Apr 9, 2019
- Finnish research looks to magnetic stimulation tech in fight against tinnitus Apr 8, 2019
- Michigan tops STAT Madness voting for pioneering device designed to treat tinnitus Apr 8, 2019
- Michigan Medicine researchers studying tinnitus reach final round in STAT Madness (“March Madness” of science) tournament Apr 4, 2019
- HEALTH NOTES: Neck patch silences ear ringing agony of tinnitus (lidocaine) Mar 30, 2019
- Update from Susan Shore: “we were able to reduce the spontaneous firing of these neurons, which resulted in reduction of the tinnitus” Mar 12, 2019
- Tinnitus: Developing effective treatments or even a cure Mar 11, 2019
- Frequency Therapeutics plans on asking the FDA to fast track FX-322, citing recent studies that link hearing loss to other diseases like depression and dementia Mar 2, 2019
- VA Now Covers Cost of the Levo System for Tinnitus Treatment Feb 26, 2019
- Another upcoming Neuromod Device podium abstract “from the future” (March 29, 2019) – with some interesting implications… Feb 22, 2019
- NEUROMOD RESULTS: “Reproducible and Long-Term Efficacy of a New Treatment for Tinnitus” Feb 19, 2019
- Professor earns award for tinnitus research Feb 11, 2019
- The future of neurostimulation: Smart neuromodulation Jan 25, 2019
- Neuromod buzzing in €24m tinnitus boost Jan 20, 2019
- Top-line results from FX-322 Phase 1/2 study are expected in the first half of 2019 Jan 7, 2019
- Frequency Therapeutics to Present at the 37th Annual JP Morgan Healthcare Conference Jan 3, 2019
- Horizon 2020 backs major push to tackle tinnitus Dec 15, 2018
- Sensorion Announces Positive Topline Results From Seliforant Phase 2a Study Dec 14, 2018
- Pitt Researchers Awarded $2 Million Grant to Develop Drug for Tinnitus Nov 12, 2018
- Frequency Therapeutics Completes Enrollment in Single Dose Safety Trial to Evaluate FX-322, a First-in-Class Drug Candidate for Hearing Restoration Oct 4, 2018
- Discovery of new neurons in the ear could lead to treatments for tinnitus Sep 12, 2018
Research
- Blast Trauma-Induced Tinnitus vs. Noise Trauma-Induced Tinnitus: Similarities and Differences Nov 27, 2019
- Medicines discovery for auditory disorders (including potential treatments for tinnitus): Challenges for industry Nov 27, 2019
- Real-time monitoring and regulating auditory cortex alpha activity in patients with chronic tinnitus Nov 14, 2019
- The effect of transcutaneous electrical nerve stimulation (TENS) on chronic subjective tinnitus Oct 29, 2019
- Noninvasive Bimodal Neuromodulation for the Treatment of Tinnitus: Protocol for a Second Large-Scale Double-Blind Randomized Clinical Trial to Optimize Stimulation Parameters Sep 27, 2019
- Efficacy and safety of bilateral caudate nucleus deep brain stimulation (DBS) for treatment-resistant tinnitus Sep 24, 2019
- Tinnitus disrupts the functioning of auditory working memory Sep 21, 2019
- Hidden hearing loss and tinnitus: utility of the high-definition audiograms in diagnosis Sep 19, 2019
- Invasive Neuromodulation as a Treatment for Tinnitus: A Systematic Review Sep 16, 2019
- A Prospective Study to Evaluate Effectiveness of a Tinnitus Relief Device (TRx) in a Clinical Setup Sep 4, 2019
- Outcomes of Triple-Combination Therapy for Chronic Tinnitus Sep 1, 2019
- Memantine Attenuates Salicylate-induced Tinnitus Possibly by Reducing NR2B Expression in Auditory Cortex of Rat Aug 31, 2019
- Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus Aug 14, 2019
- Why Is There No Cure for Tinnitus? Current Obstacles and the New Roadmap Toward a Cure Aug 6, 2019
- Sound therapy (using amplification devices and/or sound generators) for tinnitus: insufficient evidence of improvement over placebo Jul 30, 2019
- Toward An Exploration of Habituating to Tinnitus: Perspectives on Sensory Gating Jul 12, 2019
- Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies Jul 3, 2019
- Mechanism of acupuncture efficacy on tinnitus: acupuncture associated with improvement of cochlear blood flow via infrared thermography test Jun 26, 2019
- Toward Personalized Tinnitus Treatment: An Exploratory Study Based on Internet Crowdsensing Jun 25, 2019
- Treatment of Tinnitus Using Theta Burst Based Repetitive Transcranial Magnetic Stimulation-A Single Blinded Randomized Control Trial Jun 22, 2019
- Specific connectivity with Operculum 3 (OP3) brain region in acoustic trauma tinnitus Jun 20, 2019
- Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models Jun 18, 2019
- An auditory brainstem implant for treatment of unilateral tinnitus: study protocol Jun 14, 2019
- Effect of electrical stimulation at auricular points combined with sound masking on the expression of CREB, BDNF and TrkB in the auditory cortex of tinnitus rats Jun 12, 2019
- Combination of HBOT and steroids should be considered as a treatment for acute acoustic trauma in cases involving symptoms such as tinnitus and aural fullness May 28, 2019
- Effect of Tinnitus Retraining Therapy vs Standard of Care on Tinnitus-Related Quality of Life: A Randomized Clinical Trial May 23, 2019
- Earplug-induced changes in acoustic reflex thresholds suggest that increased subcortical neural gain may be necessary but not sufficient for the occurrence of tinnitus May 21, 2019
- Tinnitus-related hyper-excitation is suppressed by inhibitory dual-site repetitive transcranial magnetic stimulation (rTMS) May 15, 2019
- The short-term effects of recorded ocean sound with and without alpha frequency binaural beats on tinnitus perception May 8, 2019
- Relationship between chronic tinnitus and peripheral blood derived BDNF/GDNF promoter methylations Apr 30, 2019
- Key Findings From Tinnitus Research and Clinical Implications Apr 25, 2019
- Development of a novel middle-ear electrode for tinnitus suppression – proof of concept Apr 23, 2019
- Analysis of tinnitus patients’ hearing loss validates hypothesis on tinnitus development Apr 23, 2019
- Editorial: Translating Tinnitus Research Findings Into Clinical Practice Apr 22, 2019
- The Role of the Brainstem in Generating and Modulating Tinnitus Apr 22, 2019
- What is the difference between intermittent tinnitus and continuous tinnitus? Apr 15, 2019
- Prediction and perception: Insights for (and from) tinnitus Apr 15, 2019
- An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders Affecting Hearing, Balance and Tinnitus Pathways Apr 10, 2019
- The etiology, pathogeneses, and treatment of objective tinnitus: Unique case series and literature review Apr 5, 2019
- Complementary and Alternative Treatments for Tinnitus Apr 3, 2019
- Ethnobotanical Study of Medicinal Plants Used in Central Macedonia, Greece [Satureja montana subsp. macedonica for tinnitus and hearing loss] Apr 1, 2019
- Advances in Understanding, Diagnosis, and Treatment of Tinnitus: a Review Mar 27, 2019
- Efficacy and safety of AUT00063 versus placebo in subjective tinnitus: AUT00063 was not effective in alleviating tinnitus symptoms Mar 27, 2019
- Tinnitus Research: Improvement and Innovation Mar 24, 2019
- The potential role of auditory prediction error in preventing habituation to tinnitus Mar 20, 2019
- Effects of oral zinc supplementation on patients with noise-induced hearing loss associated tinnitus: no improvements? Mar 20, 2019
- Molecular Aspects of Melatonin Treatment in Tinnitus: a Review Mar 19, 2019
- Earplug-induced changes in acoustic reflex thresholds suggest that increased subcortical neural gain may be necessary but not sufficient for the occurrence of tinnitus Mar 16, 2019
- Comparison of Amplitude Modulated Sounds and Pure Tones at the Tinnitus Frequency: Residual Tinnitus Suppression and Stimulus Evaluation Mar 15, 2019
- Alleviation of Tinnitus With High-Frequency Stimulation of the Dorsal Cochlear Nucleus: A Rodent Study Mar 14, 2019
- Frequency-specifc activation of the peripheral auditory system using optoacoustic laser stimulation [Hubert Lim] Mar 12, 2019
- Do dietary factors significantly influence tinnitus? Mar 5, 2019
- Towards a Mechanistic-Driven Precision Medicine Approach for Tinnitus Mar 1, 2019
- Managing Patient—and Audiologist—Expectations for Tinnitus Treatment Mar 1, 2019
- AM-111 improved hearing but showed no impact on tinnitus Mar 1, 2019
- Clinical trial on tinnitus patients with normal to mild hearing loss: broad band noise and mixed pure tones sound therapy Feb 26, 2019
- Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation Feb 19, 2019
- Human caudate nucleus subdivisions in tinnitus modulation Feb 8, 2019
- Neuroprotective effects of MK-801 on auditory cortex in salicylate-induced tinnitus: Involvement of neural activity, glutamate and ascorbate Feb 1, 2019
- Emerging options in immune-mediated hearing loss Feb 1, 2019
- Residual inhibition: from the putative mechanisms to potential tinnitus treatment Feb 1, 2019
- Clinical review: The therapeutic use of theta-burst stimulation in mental disorders and tinnitus Jan 29, 2019
- Personalizing Neuromodulation Jan 24, 2019
- Single session anodal, cathodal and placebo bifrontal tDCS for treatment of intractable chronic tinnitus: A randomized controlled clinical trial Jan 22, 2019
- Adjunctive Role of Bifrontal Transcranial Direct Current Stimulation in Distressed Patients with Severe Tinnitus Jan 21, 2019
- Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC) Jan 17, 2019
- Low-intensity repetitive transcranial magnetic stimulation over prefrontal cortex in an animal model alters activity in the auditory thalamus but does not affect behavioural measures of tinnitus Jan 16, 2019
- Tinnitus Treatment Using Noninvasive and Minimally Invasive Electric Stimulation: Experimental Design and Feasibility Jan 9, 2019
- Aberrant Thalamocortical Coherence in Animal Model of Tinnitus Jan 9, 2019
- Neuronavigated Versus Non-navigated Repetitive Transcranial Magnetic Stimulation for Chronic Tinnitus: A Randomized Study Jan 7, 2019
- Does Transcranial Direct Current Stimulation Have a Role in the Treatment of Tinnitus? Jan 2, 2019
- A Pilot Randomized Controlled Trial of Transcutaneous Electrical Nerve Stimulation for Patients With Acute Tinnitus Jan 1, 2019
- Betahistine for tinnitus: no evidence to suggest an effect on tinnitus, when compared to placebo Dec 28, 2018
- Sound therapy (using amplification devices and/or sound generators) for tinnitus Dec 27, 2018
- Over-the-Counter Tinnitus “Cures”: Marketers’ Promises Do Not Ring True Dec 25, 2018
- An update: emerging drugs for tinnitus Dec 7, 2018
- Cannabinoid drugs: will they relieve or exacerbate tinnitus? Nov 29, 2018
- BOLD fMRI effects of transcutaneous vagus nerve stimulation in patients with chronic tinnitus Nov 28, 2018
- Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis Nov 26, 2018
- Traditional oriental medicine for sensorineural hearing loss: Can ethnopharmacology contribute to potential drug discovery? Nov 12, 2018
- The use of distortion product otoacoustic emissions (DPOAE) records to estimate effect of vitamin B complex on changing severity of tinnitus Nov 5, 2018
- Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus Oct 28, 2018
- Transcranial direct current stimulation for the treatment of tinnitus: a review of clinical trials and mechanisms of action Oct 25, 2018
- Reversible Sensorineural Hearing Loss Associated with Off-Label Use of Transcutaneous Vagal Nerve Stimulator Oct 1, 2018
- Unintended Consequences of White Noise Therapy for Tinnitus-Otolaryngology’s Cobra Effect: A Review Oct 1, 2018
- Tinnitus suppression using electrical stimulation Sep 22, 2018
- Rationale and Efficacy of Sound Therapies for Tinnitus and Hyperacusis Sep 20, 2018
- Totally implantable active middle ear implant: Hearing and safety results in a large series – “In subjects with preimplant tinnitus, 56.1% experienced resolution of their tinnitus. Many subjects experienced complete resolution of their tinnitus after implantation.” Sep 8, 2018
- Inhibition of Experimental Tinnitus With High Frequency Stimulation of the Rat Medial Geniculate Body Aug 13, 2018
- Change of Tinnitus with Xenon Phototherapy of the Stellate Ganglion Aug 10, 2018
- Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial Aug 2, 2018
- Characteristics of Stimulus Intensity in Transcutaneous Vagus Nerve Stimulation for Chronic Tinnitus Aug 1, 2018
- Stimulation Strategies for Tinnitus Suppression in a Neuron Model Jul 30, 2018
- Therapeutic Approaches to the Treatment of Tinnitus Jul 25, 2018
- The efficacy and safety of multiple sessions of multisite transcranial random noise stimulation in treating chronic tinnitus Jun 28, 2018
- Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial Jun 1, 2018
- MRI compatible MS2 nanoparticles designed to cross the blood–brain-barrier: providing a path towards tinnitus treatment Apr 14, 2018
- Tinnitus and neuropathic pain share a common neural substrate in the form of specific brain connectivity and microstate profiles Apr 13, 2018
- Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity Feb 27, 2018
- Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex Feb 8, 2018
- Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans Jan 3, 2018
Clinical Trials
- FX-322 in Adults With Stable Sensorineural Hearing Loss Oct 9, 2019
- Effects of Sound Stimulation, Somatosensory Stimulation, Vestibular Stimulation and the Combinations on Tinnitus Loudness and Tinnitus Related Distress in Patients Oct 8, 2019
- A Phase-II Clinical Trial on the Effectiveness of Antioxidant Supplementation in Idiopathic Tinnitus Patients [Completed] Sep 26, 2019
- OTO-313 in Subjects With Subjective Tinnitus Sep 4, 2019
- TNF-α Treatment of Blast-Induced Tinnitus Aug 23, 2019
- Deep Brain Stimulation for Tinnitus Jun 6, 2019
- Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral Tinnitus May 30, 2019
- Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation May 21, 2019
- Treatment Evaluation of Neuromodulation for Tinnitus – Stage A2 (TENT-A2) [Neuromod] Apr 30, 2019
- Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus [Withdrawn (Lack of funding and personnel)] Apr 29, 2019
- FX-322 in Sensorineural Hearing Loss [Completed] Apr 10, 2019
- Experimental Tinnitus Treatment With Transcranial Magnetic Stimulation Feb 6, 2019
- Treatment Evaluation of Neuromodulation for Tinnitus (TENT-A) [Neuromod] Jan 1, 2019
- Effects of Kinesio Taping in Patients With Somatosensory Tinnitus Dec 20, 2018
- Cochlear Promontory Stimulation for Treatment of Tinnitus Nov 30, 2018
- Regulating Homeostatic Plasticity and the Physiological Response to rTMS Nov 28, 2018
- Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts [Susan Shore] Nov 12, 2018
- Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus Oct 18, 2018
- The Study of Wuling Capsule in Treatment Chronic Tinnitus Sep 18, 2018
- Acoustic and Electrical Stimulation for the Treatment of Tinnitus Jul 23, 2018
- MRI Study of Noninvasive Transcranial Electrical Stimulation in Tinnitus Jun 8, 2018
