This page keeps track of new/upcoming treatment options for tinnitus. What’s in development? What’s promising? What’s available soon? Find out below… Current topics include FX-322, neuromodulation, Lenire, OTO-313, mGluRs, cochlear promontory stimulation, stem cells, and more. Last updated on July 30, 2019.
News
- Frequency Therapeutics prepares to advance first-in-class drug candidate FX-322 into Phase 2a study… July 23, 2019
- Otonomy Expands Recruiting Locations for Phase 1/2 Clinical Trial of OTO-313 in Patients with Subjective Tinnitus July 20, 2019
- The Truth About Tinnitus Habituation: Deficient Sensory Gating Could Explain Why Many Tinnitus Victims Do Not Habituate July 18, 2019
- Frequency Therapeutics licenses FX-322 outside U.S. to Astellas Pharma for $80M. Both companies will work on global clinical trials for the treatment and coordinate launch efforts. July 17, 2019
- New Treatment-Related Research from Dr. Susan Shore: Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies July 14, 2019
- Research Roundup: 20+ field reports from the Tinnitus Research Initiative (TRI) 2019 Conference in Taipei July 2, 2019
- New findings support the view that tinnitus could be a proprioceptive illusion related to the middle-ear muscles June 27, 2019
- Susan Shore: Cochlear damage may be necessary but not sufficient to induce tinnitus June 26, 2019
- Drug to reduce brain inflammation cured tinnitus in mice – paving the way towards a pill for humans June 18, 2019
- Reducing brain inflammation could treat tinnitus and other hearing loss-related disorders June 18, 2019
- New breakthrough pill could cure tinnitus [sensationalized headline] June 18, 2019
- Sound Pharmaceuticals Completes Phase 2 Study of SPI-1005 for the Treatment of Tinnitus and Vertigo in Patients with Meniere’s Disease June 18, 2019
- UPDATE: Frequency Therapeutics to present newest FX-322 clinical trial results on September 17, 2019 [early] June 6, 2019
- Announcement: new website for hearing loss treatment updates: HearingLossTreatmentReport.com June 2, 2019
- What’s really going on in the world of tinnitus research? Seven insights from the #TRI2019 Conference… May 31, 2019
- New study results raise serious concerns about effectiveness of Tinnitus Retraining Therapy (TRT) May 25, 2019
- Frequency Therapeutics to present major FX-322 update on September 18, 2019 at AAO-HNSF Annual Meeting in New Orleans May 18, 2019
- Possible tinnitus remedy uncovered during ethnobotanical study of medicinal plants used in Central Macedonia, Greece May 14, 2019
- Major analysis of tinnitus patients’ hearing loss points to “stochastic resonance” (SR) as root cause of tinnitus May 14, 2019
- Neuromod Broadens Senior Leadership Team in Preparation for Global Commercialisation of Lenire™ Tinnitus Treatment May 8, 2019
- Neuromod updates anticipated study completion date of device clinical trial May 8, 2019
- First study investigating the relationship between chronic tinnitus and peripheral blood derived BDNF/ GDNF promoter methylations April 30, 2019
- NEUROMOD VIDEO: “New Treatment for Tinnitus Evaluated in over 500 Patients” [Dr. Hubert Lim presentation] April 29, 2019
- Auris Medical Provides Update on Tinnitus Drug Development Strategy April 25, 2019
- Phase 1/2 clinical trial of OTO-313 (single intratympanic injection) in patients with subjective tinnitus is now recruiting April 17, 2019
- Otonomy Initiates Phase 1/2 Clinical Trial to evaluate the therapeutic potential of OTO-313 in patients with tinnitus April 11, 2019
- Biotech Frequency shows early positive results for small-molecule hearing loss therapy (FX-322) April 9, 2019
- Frequency Therapeutics Announces Positive Phase 1/2 Data for FX-322 April 9, 2019
- Finnish research looks to magnetic stimulation tech in fight against tinnitus April 8, 2019
- Michigan tops STAT Madness voting for pioneering device designed to treat tinnitus April 8, 2019
- Michigan Medicine researchers studying tinnitus reach final round in STAT Madness (“March Madness” of science) tournament April 4, 2019
- HEALTH NOTES: Neck patch silences ear ringing agony of tinnitus (lidocaine) March 30, 2019
- Update from Susan Shore: “we were able to reduce the spontaneous firing of these neurons, which resulted in reduction of the tinnitus” March 12, 2019
- Tinnitus: Developing effective treatments or even a cure March 11, 2019
- Frequency Therapeutics plans on asking the FDA to fast track FX-322, citing recent studies that link hearing loss to other diseases like depression and dementia March 2, 2019
- VA Now Covers Cost of the Levo System for Tinnitus Treatment February 26, 2019
- Another upcoming Neuromod Device podium abstract “from the future” (March 29, 2019) – with some interesting implications… February 22, 2019
- NEUROMOD RESULTS: “Reproducible and Long-Term Efficacy of a New Treatment for Tinnitus” February 19, 2019
- Professor earns award for tinnitus research February 11, 2019
- The future of neurostimulation: Smart neuromodulation January 25, 2019
- Neuromod buzzing in €24m tinnitus boost January 20, 2019
- Top-line results from FX-322 Phase 1/2 study are expected in the first half of 2019 January 7, 2019
- Frequency Therapeutics to Present at the 37th Annual JP Morgan Healthcare Conference January 3, 2019
- Horizon 2020 backs major push to tackle tinnitus December 15, 2018
- Sensorion Announces Positive Topline Results From Seliforant Phase 2a Study December 14, 2018
- Pitt Researchers Awarded $2 Million Grant to Develop Drug for Tinnitus November 12, 2018
- Frequency Therapeutics Completes Enrollment in Single Dose Safety Trial to Evaluate FX-322, a First-in-Class Drug Candidate for Hearing Restoration October 4, 2018
- Discovery of new neurons in the ear could lead to treatments for tinnitus September 12, 2018
Research
- Sound therapy (using amplification devices and/or sound generators) for tinnitus: insufficient evidence of improvement over placebo July 30, 2019
- Toward An Exploration of Habituating to Tinnitus: Perspectives on Sensory Gating July 12, 2019
- Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies July 3, 2019
- Mechanism of acupuncture efficacy on tinnitus: acupuncture associated with improvement of cochlear blood flow via infrared thermography test June 26, 2019
- Toward Personalized Tinnitus Treatment: An Exploratory Study Based on Internet Crowdsensing June 25, 2019
- Treatment of Tinnitus Using Theta Burst Based Repetitive Transcranial Magnetic Stimulation-A Single Blinded Randomized Control Trial June 22, 2019
- Specific connectivity with Operculum 3 (OP3) brain region in acoustic trauma tinnitus June 20, 2019
- Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models June 18, 2019
- An auditory brainstem implant for treatment of unilateral tinnitus: study protocol June 14, 2019
- Effect of electrical stimulation at auricular points combined with sound masking on the expression of CREB, BDNF and TrkB in the auditory cortex of tinnitus rats June 12, 2019
- Effect of Tinnitus Retraining Therapy vs Standard of Care on Tinnitus-Related Quality of Life: A Randomized Clinical Trial May 23, 2019
- Earplug-induced changes in acoustic reflex thresholds suggest that increased subcortical neural gain may be necessary but not sufficient for the occurrence of tinnitus May 21, 2019
- Tinnitus-related hyper-excitation is suppressed by inhibitory dual-site repetitive transcranial magnetic stimulation (rTMS) May 15, 2019
- The short-term effects of recorded ocean sound with and without alpha frequency binaural beats on tinnitus perception May 8, 2019
- Relationship between chronic tinnitus and peripheral blood derived BDNF/GDNF promoter methylations April 30, 2019
- Complete Recovery following Electroacupuncture Therapy in Refractory Unilateral Sensorineural Hearing Loss April 26, 2019
- Development of a novel middle-ear electrode for tinnitus suppression – proof of concept April 23, 2019
- Analysis of tinnitus patients’ hearing loss validates hypothesis on tinnitus development April 23, 2019
- Editorial: Translating Tinnitus Research Findings Into Clinical Practice April 22, 2019
- The Role of the Brainstem in Generating and Modulating Tinnitus April 22, 2019
- What is the difference between intermittent tinnitus and continuous tinnitus? April 15, 2019
- Prediction and perception: Insights for (and from) tinnitus April 15, 2019
- Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders Affecting Hearing, Balance and Tinnitus Pathways April 10, 2019
- The etiology, pathogeneses, and treatment of objective tinnitus: Unique case series and literature review April 5, 2019
- Complementary and Alternative Treatments for Tinnitus April 3, 2019
- Ethnobotanical Study of Medicinal Plants Used in Central Macedonia, Greece [Satureja montana subsp. macedonica for tinnitus and hearing loss] April 1, 2019
- Advances in Understanding, Diagnosis, and Treatment of Tinnitus: a Review March 27, 2019
- Efficacy and safety of AUT00063 versus placebo in subjective tinnitus: AUT00063 was not effective in alleviating tinnitus symptoms March 27, 2019
- Tinnitus Research: Improvement and Innovation March 24, 2019
- The potential role of auditory prediction error in preventing habituation to tinnitus March 20, 2019
- Effects of oral zinc supplementation on patients with noise-induced hearing loss associated tinnitus: no improvements? March 20, 2019
- Molecular Aspects of Melatonin Treatment in Tinnitus: a Review March 19, 2019
- Earplug-induced changes in acoustic reflex thresholds suggest that increased subcortical neural gain may be necessary but not sufficient for the occurrence of tinnitus March 16, 2019
- Comparison of Amplitude Modulated Sounds and Pure Tones at the Tinnitus Frequency: Residual Tinnitus Suppression and Stimulus Evaluation March 15, 2019
- Alleviation of Tinnitus With High-Frequency Stimulation of the Dorsal Cochlear Nucleus: A Rodent Study March 14, 2019
- Frequency-specifc activation of the peripheral auditory system using optoacoustic laser stimulation [Hubert Lim] March 12, 2019
- Do dietary factors significantly influence tinnitus? March 5, 2019
- Towards a Mechanistic-Driven Precision Medicine Approach for Tinnitus March 1, 2019
- Managing Patient—and Audiologist—Expectations for Tinnitus Treatment March 1, 2019
- AM-111 improved hearing but showed no impact on tinnitus March 1, 2019
- Clinical trial on tinnitus patients with normal to mild hearing loss: broad band noise and mixed pure tones sound therapy February 26, 2019
- Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation February 19, 2019
- Human caudate nucleus subdivisions in tinnitus modulation February 8, 2019
- Neuroprotective effects of MK-801 on auditory cortex in salicylate-induced tinnitus: Involvement of neural activity, glutamate and ascorbate February 1, 2019
- Emerging options in immune-mediated hearing loss February 1, 2019
- Residual inhibition: from the putative mechanisms to potential tinnitus treatment February 1, 2019
- Clinical review: The therapeutic use of theta-burst stimulation in mental disorders and tinnitus January 29, 2019
- Personalizing Neuromodulation January 24, 2019
- Single session anodal, cathodal and placebo bifrontal tDCS for treatment of intractable chronic tinnitus: A randomized controlled clinical trial January 22, 2019
- Adjunctive Role of Bifrontal Transcranial Direct Current Stimulation in Distressed Patients with Severe Tinnitus January 21, 2019
- Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC) January 17, 2019
- Low-intensity repetitive transcranial magnetic stimulation over prefrontal cortex in an animal model alters activity in the auditory thalamus but does not affect behavioural measures of tinnitus January 16, 2019
- Tinnitus Treatment Using Noninvasive and Minimally Invasive Electric Stimulation: Experimental Design and Feasibility January 9, 2019
- Aberrant Thalamocortical Coherence in Animal Model of Tinnitus January 9, 2019
- Neuronavigated Versus Non-navigated Repetitive Transcranial Magnetic Stimulation for Chronic Tinnitus: A Randomized Study January 7, 2019
- Does Transcranial Direct Current Stimulation Have a Role in the Treatment of Tinnitus? January 2, 2019
- A Pilot Randomized Controlled Trial of Transcutaneous Electrical Nerve Stimulation for Patients With Acute Tinnitus January 1, 2019
- Betahistine for tinnitus: no evidence to suggest an effect on tinnitus, when compared to placebo December 28, 2018
- Sound therapy (using amplification devices and/or sound generators) for tinnitus December 27, 2018
- Over-the-Counter Tinnitus “Cures”: Marketers’ Promises Do Not Ring True December 25, 2018
- An update: emerging drugs for tinnitus December 7, 2018
- Cannabinoid drugs: will they relieve or exacerbate tinnitus? November 29, 2018
- BOLD fMRI effects of transcutaneous vagus nerve stimulation in patients with chronic tinnitus November 28, 2018
- Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis November 26, 2018
- Traditional oriental medicine for sensorineural hearing loss: Can ethnopharmacology contribute to potential drug discovery? November 12, 2018
- The use of distortion product otoacoustic emissions (DPOAE) records to estimate effect of vitamin B complex on changing severity of tinnitus November 5, 2018
- Assessment of the State of the Natural Antioxidant Barrier of a Body in Patients Complaining about the Presence of Tinnitus October 28, 2018
- Transcranial direct current stimulation for the treatment of tinnitus: a review of clinical trials and mechanisms of action October 25, 2018
- Reversible Sensorineural Hearing Loss Associated with Off-Label Use of Transcutaneous Vagal Nerve Stimulator October 1, 2018
- Unintended Consequences of White Noise Therapy for Tinnitus-Otolaryngology’s Cobra Effect: A Review October 1, 2018
- Tinnitus suppression using electrical stimulation September 22, 2018
- Rationale and Efficacy of Sound Therapies for Tinnitus and Hyperacusis September 20, 2018
- Totally implantable active middle ear implant: Hearing and safety results in a large series – “In subjects with preimplant tinnitus, 56.1% experienced resolution of their tinnitus. Many subjects experienced complete resolution of their tinnitus after implantation.” September 8, 2018
- Inhibition of Experimental Tinnitus With High Frequency Stimulation of the Rat Medial Geniculate Body August 13, 2018
- Change of Tinnitus with Xenon Phototherapy of the Stellate Ganglion August 10, 2018
- Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial August 2, 2018
- Characteristics of Stimulus Intensity in Transcutaneous Vagus Nerve Stimulation for Chronic Tinnitus August 1, 2018
- Stimulation Strategies for Tinnitus Suppression in a Neuron Model July 30, 2018
- Therapeutic Approaches to the Treatment of Tinnitus July 25, 2018
- The efficacy and safety of multiple sessions of multisite transcranial random noise stimulation in treating chronic tinnitus June 28, 2018
- Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial June 1, 2018
- MRI compatible MS2 nanoparticles designed to cross the blood–brain-barrier: providing a path towards tinnitus treatment April 14, 2018
- Tinnitus and neuropathic pain share a common neural substrate in the form of specific brain connectivity and microstate profiles April 13, 2018
- Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity February 27, 2018
- Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex February 8, 2018
- Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans January 3, 2018
Clinical Trials
- OTO-313 in Subjects With Subjective Tinnitus July 17, 2019
- Deep Brain Stimulation for Tinnitus June 6, 2019
- Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral Tinnitus May 30, 2019
- Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation May 21, 2019
- Treatment Evaluation of Neuromodulation for Tinnitus – Stage A2 (TENT-A2) [Neuromod] April 30, 2019
- Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus [Withdrawn (Lack of funding and personnel)] April 29, 2019
- FX-322 in Sensorineural Hearing Loss [Completed] April 10, 2019
- Experimental Tinnitus Treatment With Transcranial Magnetic Stimulation February 6, 2019
- Treatment Evaluation of Neuromodulation for Tinnitus (TENT-A) [Neuromod] January 1, 2019
- Effects of Kinesio Taping in Patients With Somatosensory Tinnitus December 20, 2018
- Cochlear Promontory Stimulation for Treatment of Tinnitus November 30, 2018
- Regulating Homeostatic Plasticity and the Physiological Response to rTMS November 28, 2018
- Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts [Susan Shore] November 12, 2018
- Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus October 18, 2018
- The Study of Wuling Capsule in Treatment Chronic Tinnitus September 18, 2018
