This page tracks new and upcoming treatment options for tinnitus. What’s in development? What’s promising? What’s available soon? Current topics include FX-322, OTO-313, Susan Shore device, CS0022 (BMS-191011), NHPN-1010, Lenire, GW-201, Jianxin Bao, tetrandrine, OtoBand, miR‑375‑3p, and more.
Last updated: 18 hours ago
News
- Sulodexide Anticoagulant Therapy for Chronic Tinnitus: Phase 3 Clinical Trials — When? Jun 18, 2021
- Thanos Tzounopoulos explains the current state of tinnitus drug development research (and the crucial missing piece) Jun 3, 2021
- Brian Fargo, inXile founder, gives $1 million to advance UCI research for tinnitus treatment May 19, 2021
- Efficacy of donepezil in patients with chronic tinnitus May 17, 2021
- Ketamine + HD-tIPNS for tinnitus: Professor Dirk De Ridder investigates effects of new “drug/device combo” therapy May 12, 2021
- University of Granada researchers identify genes linked to severe tinnitus Apr 29, 2021
- Researchers evaluating the effects of bitter almond oil and cinnarizine on chronic tinnitus severity Apr 26, 2021
- Otonomy Now Recruiting Participants for Phase 2 Study of OTO-313 in Tinnitus [Update: New Locations Added] Apr 11, 2021
- Otonomy Initiates Phase 2 Clinical Trial of OTO-313 in Tinnitus Mar 25, 2021
- MISSING: Day-90 Study Results on Impact of FX-322 on Tinnitus… Mar 25, 2021
- American Tinnitus Association Seeking Tinnitus Research Proposals… “that may contribute to scientific understanding of tinnitus, breakthroughs in treatments, and possible cures” Mar 12, 2021
- Otolith Labs Initiates Clinical Trial of OtoBand Device as a Treatment to Reduce Perceived Loudness of Tinnitus Mar 8, 2021
- Frequency Therapeutics Announces Publication of Phase 1/2 Data Showing Hearing Improvements in Patients Receiving FX-322 Feb 22, 2021
- Otonomy Shifts Focus to Hearing Loss and Tinnitus [OTO-313] After Meniere’s Phase III Failure Feb 22, 2021
- Novel Tinnitus Drug CS0022 Reduces Chronic Tinnitus in Preclinical Study Feb 8, 2021
- Discovery of a New Type of Inhibitory Neuron [L-stellate cells] Holds Clues About Tinnitus Feb 4, 2021
- BREAKTHROUGH: NAC/HPN-07, also known as the Hough Ear Institute’s NHPN-1010, significantly reduced the incidence of tinnitus, study finds… Jan 7, 2021
- American Tinnitus Association Receives $2.7 Million Donation – Money Will Help Fund Strategic Long-Term Tinnitus Research Dec 26, 2020
- Hubert Lim on Neuromodulation and Research Behind the Lenire Device for Tinnitus [PDF] Dec 14, 2020
- What can biobanks bring to hearing, and in particular to tinnitus? Dec 4, 2020
- British Tinnitus Association awards £125k grant for research that could predict who will develop tinnitus Dec 4, 2020
- Otonomy expects to start Phase 2 trial of OTO-313 in tinnitus in first quarter of 2021 Nov 30, 2020
- In Case You Missed It: Tinnitus Hub Director Hazel Goedhart gives us the cold, hard, unbiased facts about Lenire… Nov 24, 2020
- Researchers Develop New Technology to Objectively Measure Tinnitus Nov 19, 2020
- Technology lets clinicians objectively detect tinnitus for first time Nov 18, 2020
- New FX-322 clinical trial for severe hearing loss includes tinnitus assessment as secondary outcome measure Nov 16, 2020
- The role of prediction and gain in tinnitus Nov 2, 2020
- Frequency Therapeutics Will Report FX-322 Phase 2a Study Data in Late Q1 2021 Oct 29, 2020
- Neuromod Successfully Closes $12.4 Million Series B Financing for Tinnitus Treatment Device Lenire® Oct 20, 2020
- Auckland University researchers trialing MDMA as tinnitus cure Oct 17, 2020
- Heavy metals could play important role in development of tinnitus, study finds Oct 12, 2020
- New Treatment Alleviates Ringing in the Ears: A noninvasive device [Lenire] designed to rewire brain circuits reduced symptoms of tinnitus in a large clinical trial Oct 7, 2020
- Is tinnitus all in the genes? Sep 25, 2020
- How much will FX-322 cost? David Lucchino, Frequency Therapeutics CEO, responds… Sep 24, 2020
- Frequency Therapeutics Completes Enrollment of FX-322 Phase 2a Study for Sensorineural Hearing Loss Sep 22, 2020
- Proposed “Multi-Cause Framework” of Tinnitus May Speed Up Development of New Therapies Sep 17, 2020
- Possible tinnitus gene found: Genetic variation in RCOR1 is associated with tinnitus Sep 14, 2020
- Frequency Therapeutics Presents Results Demonstrating Sustained Improvement in Hearing Loss Patients Treated with FX-322 Sep 13, 2020
- First report showing benefit of spinal cord stimulation in tinnitus Sep 12, 2020
- Dr. Will Sedley discusses role of “predictive brain processing” in tinnitus – via Tinnitus Talk [PDF] Sep 7, 2020
- British Tinnitus Association’s 2020 Tinnitus Conference Goes Virtual: October 5 – 9 Aug 27, 2020
- Not-yet-published tinnitus research preprints… Aug 26, 2020
- FX-322 phase 2a study results anticipated in second quarter of 2021… Aug 12, 2020
- Carl LeBel (Chief Development Officer at Frequency Therapeutics) talks FX-322 in latest interview – via Tinnitus Talk [PDF] Jul 25, 2020
- Update on new tinnitus drug (GW-201) from NEOMED researcher Jianxin Bao and Gateway Biotechnology Jul 20, 2020
- NEOMED researcher receives federal grant for first human tinnitus treatment Jul 15, 2020
- NIH Funds NEOMED Tinnitus Researcher Jul 8, 2020
- Otonomy Reports Positive Top-Line Results from Phase 1/2 Clinical Trial of OTO-313 in Patients with Tinnitus Jul 6, 2020
- Otonomy Provides Update on Clinical Trials: Results from Phase 1/2 trial of OTO-313 for tinnitus expected in July 2020 Jun 15, 2020
- Congressman Announces National Institute on Deafness and Other Communications Disorders Grant for Tinnitus Prevention and Treatment Jun 11, 2020
- Frequency Therapeutics Shares Clinical Data From Exploratory Study Confirming Delivery of FX-322 to the Cochlea – Top-Line Results Show Consistent Drug Entry in All Patients May 14, 2020
- FAU researchers use computer-based ‘stochastic resonance’ model of tinnitus as a basis for developing new treatment strategies May 13, 2020
- Updated list of hearing loss treatment news and research available at HearingLossTreatmentReport.com May 1, 2020
- Tinnitus Research Spotlight: A unified explanation of tinnitus development based on the Stochastic Resonance (SR) model of auditory perception Apr 21, 2020
- NO COVID-19 SLOWDOWN: Frequency Therapeutics Adds Another Recruitment Site for FX-322 Phase 2a Study (HearingLossTreatmentReport.com) Apr 14, 2020
- Treatments for tinnitus may need to enhance cortical plasticity rather than reverse it… Mar 24, 2020
- Study findings demonstrate that Lenire (Neuromod) for tinnitus “provides safe, fast-acting (within 6 weeks) and reproducible therapeutic effects that can last at least 12 months.” Mar 11, 2020
- Toward Tinnitus Subtyping: or Finding a Specific Personalized Treatment for Each Patient Feb 15, 2020
- Why Tinnitus Needs Citizen Science: A Researcher’s Perspective Feb 8, 2020
- Developing effective treatments or even a cure for tinnitus Feb 3, 2020
- Resaphene Suisse AG: Charité Ethics Committee in Berlin Approves Study on Tinniwell Tinnitus Therapy Jan 21, 2020
- Cognosetta, Inc receives funding from NIH to test a novel therapeutic for treating tinnitus (BMS-191011) Jan 14, 2020
- New ‘fast-track’ system for tinnitus and hearing loss Jan 10, 2020
- Auris Medical Receives “Intention to Grant” notice from European Patent Office for New Oral NKCC1 inhibitor Treatment for Tinnitus Jan 10, 2020
- Zilentin: Auris Medical Announces Formation of New Subsidiary for Development Projects in Tinnitus and Hearing Loss Dec 30, 2019
- American Tinnitus Association and British Tinnitus Association Partner to Spark Innovations in Tinnitus Treatments and Advance Global Discussion About Potential Tinnitus Breakthroughs Dec 10, 2019
- Proof of concept to support MDMA as a potential treatment for tinnitus? Dec 10, 2019
- Frequency Therapeutics CEO: “We have opened all U.S. sites for our Phase 2a study of FX-322 and remain on track to report top-line data in the second half of next year.” Nov 18, 2019
- RESEARCH: Experimental procedure enables suppression of auditory cortex alpha activity in patients with chronic tinnitus Nov 17, 2019
- Neuromodulation for Tinnitus Relief: Interview with Neuromod Devices CEO Dr. Ross O’Neill Oct 24, 2019
- The cortisol awakening response: could this be an effective measure of tinnitus distress? Oct 23, 2019
- FDA Grants FX-322 Fast Track Designation Oct 10, 2019
- Frequency Therapeutics Begins Recruiting for Phase 2 Study of FX-322 in Patients with Sensorineural Hearing Loss Oct 9, 2019
- VIDEO: Susan Shore on Bimodal Stimulation for Tinnitus – #TRI2019 (via TinnitusHub) Oct 8, 2019
- Neuromod (Lenire) Clinical Trial Data “Locked” Until Fall 2020? Study Results “Delayed” Until 2021? Oct 3, 2019
- Neuromod Successfully Closes €8 Million Capital Raise: proceeds will be used to accelerate ongoing commercialization of Lenire® tinnitus treatment device Sep 26, 2019
- A Breakthrough in Understanding Tinnitus: The Entire Hearing System Studied Sep 25, 2019
- Possible Link Between Marijuana Use, Tinnitus Sep 16, 2019
- Auris Medical Receives FDA and EMA Guidance for Keyzilen® (AM-101) Late-Stage Clinical Development Program Sep 13, 2019
- ABSTRACT: Phase 1/2 Hearing Loss Trial of Intratympanic FX322, a Progenitor Cell Activator Sep 11, 2019
- BREAKING: FX-322 Clinical Trial Results… Sep 6, 2019
- Auris Medical Announces Formation of Scientific Advisory Board for Tinnitus Programs Aug 26, 2019
- UA Rodent Study Identifies Possible Tinnitus Treatment Target Aug 26, 2019
- Brain Inflammation Identified as Potential Target to Treat Tinnitus Aug 20, 2019
- Tinnitus Cure Map from the British Tinnitus Association [image] Aug 6, 2019
- Frequency Therapeutics prepares to advance first-in-class drug candidate FX-322 into Phase 2a study… Jul 23, 2019
- Otonomy Expands Recruiting Locations for Phase 1/2 Clinical Trial of OTO-313 in Patients with Subjective Tinnitus Jul 20, 2019
- The Truth About Tinnitus Habituation: Deficient Sensory Gating Could Explain Why Many Tinnitus Victims Do Not Habituate Jul 18, 2019
- Frequency Therapeutics licenses FX-322 outside U.S. to Astellas Pharma for $80M. Both companies will work on global clinical trials for the treatment and coordinate launch efforts. Jul 17, 2019
- New Treatment-Related Research from Dr. Susan Shore: Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies Jul 14, 2019
- Research Roundup: 20+ field reports from the Tinnitus Research Initiative (TRI) 2019 Conference in Taipei Jul 2, 2019
- New findings support the view that tinnitus could be a proprioceptive illusion related to the middle-ear muscles Jun 27, 2019
- Susan Shore: Cochlear damage may be necessary but not sufficient to induce tinnitus Jun 26, 2019
- Drug to reduce brain inflammation cured tinnitus in mice – paving the way towards a pill for humans Jun 18, 2019
- Reducing brain inflammation could treat tinnitus and other hearing loss-related disorders Jun 18, 2019
- New breakthrough pill could cure tinnitus [sensationalized headline] Jun 18, 2019
- Sound Pharmaceuticals Completes Phase 2 Study of SPI-1005 for the Treatment of Tinnitus and Vertigo in Patients with Meniere’s Disease Jun 18, 2019
- UPDATE: Frequency Therapeutics to present newest FX-322 clinical trial results on September 17, 2019 [early] Jun 6, 2019
- What’s really going on in the world of tinnitus research? Seven insights from the #TRI2019 Conference… May 31, 2019
- New study results raise serious concerns about effectiveness of Tinnitus Retraining Therapy (TRT) May 25, 2019
Research
- The Neuroscience and the Treatment of Tinnitus: what is the crucial missing piece in tinnitus research? May 28, 2021
- Insufficient Evidence: Gabapentin’s Efficacy in Tinnitus Treatment – A Systematic Review May 26, 2021
- Role of microRNA‑375‑3p‑mediated regulation in tinnitus development May 21, 2021
- Cochlear nucleus small cells use olivocochlear collaterals to encode sounds in noise [Preprint] [Susan Shore] May 21, 2021
- Auditory thalamus dysfunction and pathophysiology in tinnitus: a predictive network hypothesis May 2, 2021
- The bewitched ear: State of the art genomics research on tinnitus Apr 24, 2021
- Activity of CaMKIIa+ dorsal cochlear nucleus neurons are crucial for tinnitus perception but not for tinnitus induction [Preprint] Apr 8, 2021
- Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study Apr 1, 2021
- What’s the Buzz? The Neuroscience and the Treatment of Tinnitus [Thanos Tzounopoulos] Mar 26, 2021
- Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank Mar 19, 2021
- Effectiveness of photobiomodulation in the management of tinnitus remains debatable: A systematic review Mar 5, 2021
- Increased Serum Lipid Levels in Patients with Subjective Tinnitus Feb 21, 2021
- Development of Ebselen for the Treatment of Sensorineural Hearing Loss and Tinnitus Feb 19, 2021
- The progression of chronic tinnitus over the years Feb 18, 2021
- Pharmacological Evaluation of Drugs in Animal Models of Tinnitus Feb 16, 2021
- Transient Delivery of a KCNQ2/3-Specific Channel Activator [RL-81] 1 Week After Noise Trauma Mitigates Noise-Induced Tinnitus Feb 11, 2021
- Using cortical neuron markers to target cells in the dorsal cochlear nucleus: new means for treatment of bothersome tinnitus? Feb 9, 2021
- Glucose Control Has an Impact on Cerebral Blood Flow Alterations in Chronic Tinnitus Patients Feb 4, 2021
- Altering activity in the peripheral nerve may be a viable target for early pharmaceutical intervention in forms of tinnitus originating in the cochlea Feb 3, 2021
- Spontaneous firing patterns in the medial geniculate nucleus in a guinea pig model of tinnitus Jan 30, 2021
- The BDNF Val66 Met polymorphism regulates vulnerability to chronic stress and phantom perception Jan 22, 2021
- Metabolic changes in the brain and blood of rats following acoustic trauma, tinnitus and hyperacusis Jan 19, 2021
- Review: Neural Mechanisms of Tinnitus and Hyperacusis Jan 19, 2021
- Noise Exposure Alters Glutamatergic and GABAergic Synaptic Connectivity in the Hippocampus and Its Relevance to Tinnitus Jan 15, 2021
- Efficacy of fluoxetine vs. fluoxetine plus alprazolam in treatment of chronic tinnitus: No reduction in Tinnitus Severity Index (TSI) Jan 15, 2021
- Towards personalized rTMS in tinnitus: reliability of individualized stimulation protocols in behavioral and electrophysiological responses [Preprint] Jan 13, 2021
- Tinnitus-like “hallucinations” elicited by sensory deprivation in an entropy maximization recurrent neural network [Preprint] Jan 11, 2021
- Electrophysiological assessment and pharmacological treatment of blast-induced tinnitus Jan 7, 2021
- Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma Jan 5, 2021
- Prediction of Acoustic Residual Inhibition of Tinnitus Using a Brain-Inspired Spiking Neural Network Model Jan 5, 2021
- Low-Level Laser Therapy as a Therapeutic Strategy for Patients With Tinnitus: Not Yet Proven Dec 29, 2020
- ATP-sensitive K+ channels control the spontaneous firing of a glycinergic interneuron in the auditory brainstem Dec 28, 2020
- Subcortical and cortical responses are enlarged in tinnitus patients with hyperacusis compared to those without hyperacusis Dec 24, 2020
- Systematic review and meta-analysis of late auditory evoked potentials as a candidate biomarker in the assessment of tinnitus Dec 17, 2020
- Neurophysiological correlates of residual inhibition in tinnitus: Hints for trait-like EEG power spectra Dec 16, 2020
- Gray matter declines with age and hearing loss, but is partially maintained in tinnitus Dec 11, 2020
- Purinergic signaling controls spontaneous activity in the auditory system throughout early development Dec 10, 2020
- A Review and a Framework of Variables for Defining and Characterizing Tinnitus Subphenotypes Dec 4, 2020
- A tale of two tinnituses: Does hearing status influence central tinnitus localization? Dec 3, 2020
- Efficacy of Low-Level Laser Therapy for Tinnitus: A Systematic Review with Meta-Analysis and Trial Sequential Analysis Dec 2, 2020
- Tinnitus and auditory cortex: using adapted functional near-infrared spectroscopy to measure resting-state functional connectivity Nov 27, 2020
- Association Between Tinnitus Pitch and Consonant Recognition in Noise Nov 25, 2020
- Switching Tinnitus-On: Maps and source localization of spontaneous EEG Nov 23, 2020
- Cannabinoids, Inner Ear, Hearing, and Tinnitus: A Neuroimmunological Perspective Nov 23, 2020
- A Gradient of Sharpening Effects by Perceptual Prior across the Human Cortical Hierarchy Nov 18, 2020
- Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning Nov 18, 2020
- Tinnitus impairs segregation of competing speech in normal-hearing listeners Nov 16, 2020
- Increased central gain caused by reduced auditory input is a major mechanism of tinnitus but may originate from other pathophysiologic factors rather than from cochlear synaptopathy Nov 10, 2020
- Tinnitus Symptoms Improve With Sound and Tongue Stimulation Nov 10, 2020
- What Makes Tinnitus Loud? Nov 8, 2020
- Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem Nov 5, 2020
- Effect of age on the gap-prepulse inhibition of the cortical N1-P2 complex in humans as a step towards an objective measure of tinnitus Nov 5, 2020
- Does the tinnitus pitch correlate with the frequency of hearing loss? Nov 4, 2020
- Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus Nov 3, 2020
- A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response Oct 30, 2020
- Dietary Factors and Tinnitus among Adolescents Oct 27, 2020
- The Prevalence of Different Types of Headache in Patients with Subjective Tinnitus and Its Influence on Tinnitus Parameters: A Prospective Clinical Study Oct 24, 2020
- Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus Oct 13, 2020
- Noise Induced Hearing Loss and Tinnitus-New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention Oct 13, 2020
- The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus Oct 9, 2020
- Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study Oct 7, 2020
- High Definition transcranial Direct Current Stimulation (HD-tDCS) for chronic tinnitus: outcomes from a prospective longitudinal large cohort study [Preprint] Oct 2, 2020
- Phenotyping chronic tinnitus patients using self-report questionnaire data: cluster analysis and visual comparison Oct 2, 2020
- How can sound generating devices support coping with tinnitus? Oct 1, 2020
- A New Buzz for Tinnitus—It’s in the Genes! Sep 24, 2020
- Novel Genetic Risk Loci Associated with Tinnitus and Causal Inference with Hearing Loss and Neuropsychiatric Disorders and Traits Sep 24, 2020
- Individualized Treatment of Tinnitus during Sleep Using Stimulation of the Auditory and Limbic Systems Sep 23, 2020
- Using cortical neuron markers to target cells in the dorsal cochlear nucleus: novel tools for studying tinnitus mechanisms [Preprint] Sep 20, 2020
- Perceptual Dimensions Underlying Tinnitus-Like Sounds Sep 18, 2020
- Dual-site rTMS is More Effective than Single-site rTMS in Tinnitus Patients: A Blinded Randomized Controlled Trial Sep 17, 2020
- The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants Sep 16, 2020
- Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study [Preprint] Sep 15, 2020
- Glutamatergic modulation of auditory cortex connectivity with attentional brain networks in unpredictable perceptual environment Sep 14, 2020
- Genetic variation in RCOR1 is associated with tinnitus in UK Biobank [Preprint] Sep 13, 2020
- From Acute to Chronic Tinnitus: Pilot Data on Predictors and Progression Sep 11, 2020
- Proteasome Activity in the Plasma as a Novel Biomarker in Mild Cognitive Impairment with Chronic Tinnitus Sep 11, 2020
- Mechanisms Underlying Enhancement of Spontaneous Glutamate Release by Group I mGluRs at a Central Auditory Synapse Sep 9, 2020
- Transcranial direct current stimulation improves tinnitus perception and modulates cortical electrical activity in patients with tinnitus: A randomized clinical trial Aug 28, 2020
- Loud noise exposure differentially affects subpopulations of auditory cortex pyramidal cells [Preprint] Aug 25, 2020
- Tinnitus severity significantly worse in patients with hearing loss than patients with normal hearing Aug 13, 2020
- Acupuncture for tinnitus: level of evidence insufficient to draw any definitive conclusions Aug 10, 2020
- Uncovering the Contribution of Enhanced Central Gain and Altered Cortical Oscillations to Tinnitus Generation Aug 9, 2020
- Susceptibility to Residual Inhibition is Associated with Hearing Loss and Tinnitus Chronicity [Preprint] Aug 6, 2020
- Single nucleotide polymorphisms in tinnitus patients exhibiting severe distress: severity of tinnitus is associated with genetic background Aug 3, 2020
- Analysis of cerebellum with magnetic resonance 3D T1 sequence in individuals with chronic subjective tinnitus Aug 3, 2020
- Association between Hyperacusis and Tinnitus Jul 28, 2020
- The Efficacy of Intratympanic Steroid Injection (Dexamethasone) in Tinnitus Cases Unresponsive to Medical Treatment Jul 28, 2020
- Analysis of Auditory Brainstem Response Change, according to Tinnitus Duration, in Patients with Tinnitus with Normal Hearing Jul 28, 2020
- Differences in Clinical Characteristics and Brain Activity between Patients with Low- and High-Frequency Tinnitus Jul 26, 2020
- Loss of Cochlear Ribbon Synapse Is a Critical Contributor to Chronic Salicylate Sodium Treatment-Induced Tinnitus without Change Hearing Threshold Jul 25, 2020
- Genetic Inheritance and Its Contribution to Tinnitus Jul 24, 2020
- A Case Report of High Cervical Spinal Cord Stimulation for Chronic Otalgia and Tinnitus Jul 23, 2020
- Increasing endogenous activity of NMDARs on GABAergic neurons prevents noise-induced tinnitus Jul 20, 2020
- Nitric oxide increases gain within the ventral cochlear nucleus of guinea pigs with tinnitus Jul 19, 2020
- Potential Role of Noninvasive Brain Stimulation Interventions (NIBS) in Tinnitus Management Jul 9, 2020
- The sound-sensitive tinnitus index: Psychometric properties of a scale to assess the impact of tinnitus exacerbated by sound Jul 9, 2020
- Fluctuations in Subjective Tinnitus Ratings Over Time: Implications for Clinical Research Jul 3, 2020
- Long-lasting total remission of tinnitus: A systematic collection of cases Jul 2, 2020
- Total remission or persistence of tinnitus and decreased sound level tolerance in adolescents with normal audiograms: A follow-up study Jul 2, 2020
- Evidence of Reorganization of Brain White Matter in Persistent Idiopathic Tinnitus Patients Without Hearing Loss Suggests Close Relationship Between Tinnitus and Limbic System Jul 2, 2020
- Dorsomedial Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation (rTMS) for Tinnitus: Results of a Blinded, Randomized, Sham-Controlled Study Jul 2, 2020
- Auditory Neural Plasticity in Tinnitus Mechanisms and Management Jul 1, 2020
- Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss Jun 30, 2020
- Non-Invasive Neuromodulation for Tinnitus Jun 25, 2020
- Impact of Acamprosate on Chronic Tinnitus: a subjective relief of tinnitus and some degree of electrophysiological improvement Jun 5, 2020
- High mean platelet volume and neutrophil to lymphocyte ratio values are associated with idiopathic tinnitus, suggesting the role of vascular pathologies in etiology of tinnitus Jun 4, 2020
- Improved pure tone sensitivity after simulated hearing loss [Preprint] May 31, 2020
- Transcutaneous Electrical Nerve Stimulation (TENS) for Treatment of Tinnitus: a safe and feasible intervention option May 28, 2020
- Altered Topological Patterns of Gray Matter Networks in Tinnitus: A Graph-Theoretical-Based Study May 27, 2020
- Associations Between Subjective Tinnitus and Cognitive Performance: Systematic Review and Meta-Analyses May 21, 2020
- Binaural Interaction in Tinnitus Patients: the presence of binaural processing deficits in tinnitus patients May 13, 2020
- Tinnitus associated with benzodiazepine withdrawal syndrome: a rare but debilitating and long-term risk May 7, 2020
- Avenue for Future Tinnitus Treatments May 4, 2020
- Heritability and Genetics Contribution to Tinnitus Apr 22, 2020
- Current Device-based Clinical Treatments for Tinnitus Apr 22, 2020
- Regulation of auditory plasticity during critical periods and following hearing loss: associations with tinnitus Apr 20, 2020
- Microstate in resting state: an EEG indicator of tinnitus? Apr 17, 2020
- The Stochastic Resonance model of auditory perception: A unified explanation of tinnitus development, Zwicker tone illusion, and residual inhibition Mar 29, 2020
- Cortical Tonotopic Map Changes in Humans are Larger in Hearing Loss than in additional Tinnitus Mar 19, 2020
- Investigating functional changes in the brain to intermittently induced auditory illusions and its relevance to chronic tinnitus Mar 10, 2020
- Relationship Between Diet, Tinnitus, and Hearing Difficulties Mar 1, 2020
- Effects of Vibrant Soundbridge (VSB) on Tinnitus Accompanied by Sensorineural Hearing Loss Feb 4, 2020
- Beyond Hearing Loss: Does Tinnitus Cause Cognitive Impairment? Feb 1, 2020
- Plasticity in Limbic Regions at Early Time Points in Experimental Models of Tinnitus Jan 24, 2020
- A mouse model for temporary and persistent tinnitus using the gap startle paradigm Jan 22, 2020
- Is there an association between the parameters of arterial stiffness and tinnitus? Jan 13, 2020
- A 7 Tesla fMRI Investigation of Human Tinnitus Percept in Cortical and Subcortical Auditory Areas Jan 11, 2020
- Perceptual Modeling of Tinnitus Pitch and Loudness Jan 8, 2020
- Single dose of hallucinogenic compound 5-MeO-DMT can be effective in treating tinnitus-related anxiety Jan 8, 2020
- Cognitive behavioural therapy for tinnitus: uncertainty remains due to concerns about quality of evidence and an absence of evidence at 6 or 12 months follow-up Jan 8, 2020
- A proof-of-principle study of the short-term effects of 3,4-methylenedioxymethamphetamine (MDMA) on tinnitus and neural connectivity Jan 6, 2020
- Amplitude Modulated Noise for Tinnitus Suppression in Tonal and Noise-Like Tinnitus Jan 6, 2020
- The effect of fibromyalgia treatment on tinnitus Jan 3, 2020
- Altered functional connectivity of the thalamus in tinnitus patients is correlated with symptom alleviation after sound therapy Jan 3, 2020
- Within-Subject Analysis of Auditory Brain Stem Responses in Adults With Unilateral Tinnitus Dec 26, 2019
- Ginkgo biloba for tinnitus – Cochrane Database of Systematic Reviews Dec 23, 2019
- In support of a striatal gating model of tinnitus: new biomarkers to monitor and target specific brain areas for neuromodulation therapies Dec 20, 2019
- Abnormal Spontaneous Neural Activity of the Central Auditory System Changes the Functional Connectivity in the Tinnitus Brain Dec 20, 2019
- Enhancement of VGLUT3 expression in cochlear inner hair cells may contribute to the pathogenesis of tinnitus Dec 19, 2019
- Analysis of the audiological characteristics and comorbidity in patients with chronic tinnitus Dec 19, 2019
- Morphological Neuroimaging Biomarkers for Tinnitus: Evidence Obtained by Applying Machine Learning Dec 13, 2019
- The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial Dec 12, 2019
- Treatment Outcome of Auditory and Frontal Dual-Site rTMS in Tinnitus Patients: A beneficial effect of rTMS on tinnitus suppression Dec 12, 2019
- Intensity Mismatch Asymmetry (IMA): a new tinnitus biomarker based on a prediction resetting model of tinnitus generation Dec 11, 2019
- A proof-of-principle study of the short-term effects of MDMA (3,4-methylenedioxymethamphetamine) on tinnitus and neural connectivity Dec 7, 2019
- Chronic Tinnitus Exhibits Bidirectional Functional Dysconnectivity in Frontostriatal Circuit Dec 6, 2019
- Blast Trauma-Induced Tinnitus vs. Noise Trauma-Induced Tinnitus: Similarities and Differences Nov 27, 2019
- Medicines discovery for auditory disorders (including potential treatments for tinnitus): Challenges for industry Nov 27, 2019
- Real-time monitoring and regulating auditory cortex alpha activity in patients with chronic tinnitus Nov 14, 2019
- Tinnitus and event related potentials: a systematic review Nov 4, 2019
- Maladaptive alterations of resting state cortical network in Tinnitus Oct 29, 2019
- The effect of transcutaneous electrical nerve stimulation (TENS) on chronic subjective tinnitus Oct 29, 2019
- Missed Hearing Loss in Tinnitus Patients With Normal Audiograms Oct 17, 2019
- Noninvasive Bimodal Neuromodulation for the Treatment of Tinnitus: Protocol for a Second Large-Scale Double-Blind Randomized Clinical Trial to Optimize Stimulation Parameters Sep 27, 2019
- Efficacy and safety of bilateral caudate nucleus deep brain stimulation (DBS) for treatment-resistant tinnitus Sep 24, 2019
- Tinnitus disrupts the functioning of auditory working memory Sep 21, 2019
- Hidden hearing loss and tinnitus: utility of the high-definition audiograms in diagnosis Sep 19, 2019
- Invasive Neuromodulation as a Treatment for Tinnitus: A Systematic Review Sep 16, 2019
- Auditory Brainstem Response in Patients With Tinnitus Associated With Vitamin B12 Deficiency Sep 15, 2019
- A Prospective Study to Evaluate Effectiveness of a Tinnitus Relief Device (TRx) in a Clinical Setup Sep 4, 2019
- Outcomes of Triple-Combination Therapy for Chronic Tinnitus Sep 1, 2019
- Memantine Attenuates Salicylate-induced Tinnitus Possibly by Reducing NR2B Expression in Auditory Cortex of Rat Aug 31, 2019
- Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus Aug 14, 2019
- Why Is There No Cure for Tinnitus? Current Obstacles and the New Roadmap Toward a Cure Aug 6, 2019
- Sound therapy (using amplification devices and/or sound generators) for tinnitus: insufficient evidence of improvement over placebo Jul 30, 2019
- Toward An Exploration of Habituating to Tinnitus: Perspectives on Sensory Gating Jul 12, 2019
- Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies Jul 3, 2019
- Mechanism of acupuncture efficacy on tinnitus: acupuncture associated with improvement of cochlear blood flow via infrared thermography test Jun 26, 2019
- Toward Personalized Tinnitus Treatment: An Exploratory Study Based on Internet Crowdsensing Jun 25, 2019
- Treatment of Tinnitus Using Theta Burst Based Repetitive Transcranial Magnetic Stimulation-A Single Blinded Randomized Control Trial Jun 22, 2019
- Specific connectivity with Operculum 3 (OP3) brain region in acoustic trauma tinnitus Jun 20, 2019
- Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models Jun 18, 2019
- Effect of electrical stimulation at auricular points combined with sound masking on the expression of CREB, BDNF and TrkB in the auditory cortex of tinnitus rats Jun 12, 2019
- Effect of Tinnitus Retraining Therapy vs Standard of Care on Tinnitus-Related Quality of Life: A Randomized Clinical Trial May 23, 2019
- Changes in gene expression following sudden loss of auditory input in one ear may contribute to perceptual disorders such as tinnitus and hyperacusis May 21, 2019
- Tinnitus-related hyper-excitation is suppressed by inhibitory dual-site repetitive transcranial magnetic stimulation (rTMS) May 15, 2019
- The short-term effects of recorded ocean sound with and without alpha frequency binaural beats on tinnitus perception May 8, 2019
- Relationship between chronic tinnitus and peripheral blood derived BDNF/GDNF promoter methylations Apr 30, 2019
- Key Findings From Tinnitus Research and Clinical Implications Apr 25, 2019
- Development of a novel middle-ear electrode for tinnitus suppression – proof of concept Apr 23, 2019
- Analysis of tinnitus patients’ hearing loss validates hypothesis on tinnitus development Apr 23, 2019
- Editorial: Translating Tinnitus Research Findings Into Clinical Practice Apr 22, 2019
- The Role of the Brainstem in Generating and Modulating Tinnitus Apr 22, 2019
- What is the difference between intermittent tinnitus and continuous tinnitus? Apr 15, 2019
- Prediction and perception: Insights for (and from) tinnitus Apr 15, 2019
- An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders Affecting Hearing, Balance and Tinnitus Pathways Apr 10, 2019
- Complementary and Alternative Treatments for Tinnitus Apr 3, 2019
- Ethnobotanical Study of Medicinal Plants Used in Central Macedonia, Greece [Satureja montana subsp. macedonica for tinnitus and hearing loss] Apr 1, 2019
- Advances in Understanding, Diagnosis, and Treatment of Tinnitus: a Review Mar 27, 2019
- Efficacy and safety of AUT00063 versus placebo in subjective tinnitus: AUT00063 was not effective in alleviating tinnitus symptoms Mar 27, 2019
- Tinnitus Research: Improvement and Innovation Mar 24, 2019
- The potential role of auditory prediction error in preventing habituation to tinnitus Mar 20, 2019
- Effects of oral zinc supplementation on patients with noise-induced hearing loss associated tinnitus: no improvements? Mar 20, 2019
- Molecular Aspects of Melatonin Treatment in Tinnitus: a Review Mar 19, 2019
- Earplug-induced changes in acoustic reflex thresholds suggest that increased subcortical neural gain may be necessary but not sufficient for the occurrence of tinnitus Mar 16, 2019
- Comparison of Amplitude Modulated Sounds and Pure Tones at the Tinnitus Frequency: Residual Tinnitus Suppression and Stimulus Evaluation Mar 15, 2019
- Alleviation of Tinnitus With High-Frequency Stimulation of the Dorsal Cochlear Nucleus: A Rodent Study Mar 14, 2019
- Frequency-specifc activation of the peripheral auditory system using optoacoustic laser stimulation [Hubert Lim] Mar 12, 2019
- Do dietary factors significantly influence tinnitus? Mar 5, 2019
- Towards a Mechanistic-Driven Precision Medicine Approach for Tinnitus Mar 1, 2019
Clinical Trials
- OTO-313 in Subjects With Unilateral Subjective Tinnitus Jun 11, 2021
- Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus May 25, 2021
- Evaluation of the OtoBand as a Treatment to Reduce the Perceived Loudness of Tinnitus May 10, 2021
- Cochlear Promontory Stimulation for Treatment of Tinnitus Apr 30, 2021
- An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus Apr 29, 2021
- Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss [Diagnostic] Apr 28, 2021
- Effect of Highly Bioavailable Curcumin on Subjective Tinnitus Mar 16, 2021
- Effectiveness of Intratympanic Dexamethasone With Lignocaine for Alleviation of Tinnitus Mar 15, 2021
- Daily Bitemporal Low-frequency Transcranial Random Noise Stimulation in Tinnitus (tRNS2-tin) Jan 20, 2021
- Acoustic and Electrical Stimulation for the Treatment of Tinnitus Jan 14, 2021
- Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts Nov 13, 2020
- Investigating Accelerated Learning in Tinnitus Participants Implanted With Vagus Nerve Stimulation [Suspended] Nov 4, 2020
- Novel Tinnitus Implant System for the Treatment of Chronic Severe Tinnitus Oct 19, 2020
- Transcranial Electrical and Acoustic Stimulation for Tinnitus Sep 16, 2020
- ICCAC-ToNF EEG Neurofeedback Training & Tinnitus Sep 4, 2020
- MRI Study of Noninvasive Transcranial Electrical Stimulation in Tinnitus Aug 31, 2020
- High Dose Oxytocin Nasal Spray for Treatment of Tinnitus Aug 14, 2020
- OTO-313 in Subjects With Subjective Tinnitus [Completed] Jun 17, 2020
- Treatment of Tinnitus With Migraine Medications May 27, 2020
- Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus May 22, 2020
- Deep Brain Stimulation for Tinnitus Mar 23, 2020
- Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS) Mar 5, 2020
- Phase 2a Efficacy Study of FX-322 in Adults With Stable Sensorineural Hearing Loss Jan 29, 2020
- Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation [Terminated] Dec 19, 2019
- Novel Tinnitus Implant System for the Treatment of Chronic Severe Tinnitus Nov 19, 2019
- Effects of Sound Stimulation, Somatosensory Stimulation, Vestibular Stimulation and the Combinations on Tinnitus Loudness and Tinnitus Related Distress in Patients Oct 8, 2019
- A Phase-II Clinical Trial on the Effectiveness of Antioxidant Supplementation in Idiopathic Tinnitus Patients [Completed] Sep 26, 2019
- Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral Tinnitus May 30, 2019
- Individualized Treatment of Patients With Chronic Tinnitus With Repetitive Transcranial Magnetic Stimulation May 21, 2019
- Treatment Evaluation of Neuromodulation for Tinnitus – Stage A2 (TENT-A2) [Neuromod] Apr 30, 2019
- Acoustic Stimulation Paired With Body and Cortical Stimulation for Modulating Tinnitus [Withdrawn (Lack of funding and personnel)] Apr 29, 2019
- FX-322 in Sensorineural Hearing Loss [Completed] Apr 10, 2019
- Experimental Tinnitus Treatment With Transcranial Magnetic Stimulation Feb 6, 2019
- Treatment Evaluation of Neuromodulation for Tinnitus (TENT-A) [Neuromod] Jan 1, 2019
- Effects of Kinesio Taping in Patients With Somatosensory Tinnitus Dec 20, 2018
- Regulating Homeostatic Plasticity and the Physiological Response to rTMS Nov 28, 2018
- Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts [Susan Shore] Nov 12, 2018
- The Study of Wuling Capsule in Treatment Chronic Tinnitus Sep 18, 2018
