Researchers evaluating the effects of bitter almond oil and cinnarizine on chronic tinnitus severity

A new phase 3 clinical trial for tinnitus has begun recruiting at Mazandaran University of Medical Sciences, a top medical university in Iran.

Researchers will investigate whether or not a combination of bitter almond oil and cinnarizine can reduce tinnitus severity in patients with chronic tinnitus.

The title of the study is “The Efficacy of bitter almond oil on the severity of chronic tinnitus.”

Iran bitter almond oil tinnitus study
This study was found “hiding” on a little-known Iranian clinical trial registry. We verified it by cross-referencing the study’s unique registration identifiers in a WHO database as well as the Cochrane Central Register of Clinical Trials.

Participants in the treatment group will receive a combination of bitter almond ear drops and cinnarizine tablets, twice daily (every 12 hours), for one month.

Tinnitus severity will be measured thrice three times: 1) immediately before treatment begins, 2) after two weeks of treatment, and 3) after 4 weeks of treatment, using VAS and THI scores.

This trial was registered on February 16, 2021 and will enroll up to 70 patients with doctor-confirmed chronic tinnitus, between the ages of 17 and 75, male and/or female.

As of March 1, 2021, recruiting for this study was set to begin on March 5, 2021. No reason to assume that date has changed. But we will update this post as we get more information.

As for the treatment itself – a unique combination of ear drops and tablets – here is some very basic background information:

More information on bitter almond oil will follow. For now, an important warning:

WARNING: “bitter almond oil” might sound like a harmless natural ingredient, but in reality it is associated with some extremely serious chemical compounds (i.e. cyanide). Needless to say, there is NO safe (or legal) do-it-yourself approach to copying this trial. Or any trial, for that matter… but especially this trial.

Some interesting information on the cinnarizine component, from the Meniere’s Society UK:

Cinnarizine has two pharmacological actions. It is a calcium antagonist, though not a powerful one. This acts mainly on the blood vessels and prevents constriction on these vessels. In theory it therefore improves the micro circulation of the ear. At the same time it has a mild antihistaminic effect.

Remember to subscribe to the email newsletter for updates related to this cinnarizine/bitter almond combination therapy (and news about other experimental tinnitus treatments in development).


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