Heavy metals could play important role in development of tinnitus, study finds

Quick research update…

New paper outlines how elevated levels of manganese, cadmium, chromium, and selenium could potentially be the cause of subjective tinnitus.

Authors conclude that supplementation or reduction of these heavy metal elements “could be considered as novel therapeutic goals” for treating tinnitus.

Further studies are necessary. For now, here is the abstract for the study, The Role of Manganese, Cadmium, Chromium and Selenium on Subjective Tinnitus, published October 9, 2020:

Elevated levels of heavy metals like cadmium (Cd) and manganese (Mn) are known to lead to oxidative damage-related oto-toxicity and decreased levels of chromium (Cr) and selenium (Se) are known to lead to oto-toxicity due to reduced anti-oxidant activity. The aim of the present study was to evaluate serum levels of Cd, Mn, Cr, and Se and their relationship with tinnitus. A total of 48 patients with tinnitus (Group 1) and 40 healthy controls (Group 2) were included in the study. All participants were applied audiology tests. Severity of tinnitus was measured with Tinnitus Severity Index Questionnaire (TSIQ) in group 1. Serum Mn, Cd, Cr, and Se measurements were done by using The Agilent ICP-MS system consisted of a 7700 coupled plasma mass spectrometry (ICP-MS). Serum Cd, Mn, and Cr levels were higher in group 1 and Se level was lower in group 1 than that of group 2. We may conclude that Cd, Mn, Cr, and Se levels could play an important role in etio-pathogenesis of tinnitus, and thereby supplementation or reduction of these elements could be considered as novel therapeutic goals.



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