CATEGORY:
Research
TITLE:
Glucose Control Has an Impact on Cerebral Blood Flow Alterations in Chronic Tinnitus Patients
DESCRIPTION:
CONCLUSION: Tinnitus affects brain perfusion in the auditory area and DMN. T2DM and uncontrolled glucose levels may aggravate a CBF decrease in tinnitus patients. These new findings implied that tinnitus patients may benefit from blood glucose control in terms of their cognitive function and tinnitus distress.
CONTENT:
Front Neurosci. 2021 Feb 4;14:623520. doi: 10.3389/fnins.2020.623520. eCollection 2020.
ABSTRACT
PURPOSE: Both tinnitus and type 2 diabetes mellitus (T2DM) are linked with cognitive decline and brain dysfunction. This study used arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) to examine the abnormal cerebral blood flow (CBF) patterns existed in tinnitus patients and potential relationships between the abnormal CBF and cognitive performance. The impact of T2DM on CBF alterations in tinnitus patients was further explored.
METHODS: Sixty tinnitus patients and 40 non-tinnitus subjects were recruited. CBF images were collected and analyzed using ASL perfusion fMRI. Brain regions with CBF alterations between tinnitus patients and non-tinnitus controls were identified by one-way analysis of variance. Interaction effects between tinnitus and T2DM for CBF changes were also selected. Then, correlation analyses were calculated to specify the link between CBF changes and cognitive performance and between CBF changes and diabetic characteristics.
RESULTS: Tinnitus patients showed decreased CBF, primarily in the auditory area and default mode network (DMN), compared with non-tinnitus controls. Decreased CBF in these regions was correlated with executive function and attention. The interaction effect between tinnitus and T2DM was significant in the right medial prefrontal gyrus. Additionally, CBF in the right medial prefrontal gyrus was correlated with tinnitus distress and cognitive performance. In tinnitus patients, Hemoglobin A1c was associated with CBF in the right medial prefrontal gyrus.
CONCLUSION: Tinnitus affects brain perfusion in the auditory area and DMN. T2DM and uncontrolled glucose levels may aggravate a CBF decrease in tinnitus patients. These new findings implied that tinnitus patients may benefit from blood glucose control in terms of their cognitive function and tinnitus distress.
PMID:33633528 | PMC:PMC7902065 | DOI:10.3389/fnins.2020.623520
SOURCE:
Frontiers in neuroscience
DATE – PUBLISHED:
2021-02-04T07:33:52Z
DATE – DOI: 2021-02-04T07:33:52Z
DATE – PUBMED: 2021 Feb 4
DATE OUTPUT MATCHED: True
DATE – ADDED:
Fri, 26 Feb 2021 06:00:00 -0500
DATE – RETRIEVED:
02/26/21 07:59AM
2021-02-26T07:59:11-05:00
IDENTIFIER:
pmid:33633528,pmc:PMC7902065,doi:10.3389/fnins.2020.623520
PUBMED ID:
pubmed:33633528
DOI:
10.3389/fnins.2020.623520
LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/33633528/
LINK – DOI:
https://doi.org/10.3389/fnins.2020.623520
LINK – PUBLISHER:
https://www.frontiersin.org/articles/10.3389/fnins.2020.623520/full
REFERENCES:
Tinnitus Treatment Report, Urgent Research, 2021-02-26T07:59:11-05:00, www.tinnitustreatmentreport.com.
