https://www.tinnitus.org.uk/blog/is-tinnitus-all-in-the-genes
Is tinnitus all in the genes?
www.TinnitusTreatmentReport.com
https://www.tinnitus.org.uk/blog/is-tinnitus-all-in-the-genes
Is tinnitus all in the genes?
https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2770968
September 24, 2020
A New Buzz for Tinnitus—It’s in the Genes!
Christopher R. Cederroth, PhD1,2,3; Natalia Trpchevska, MD3; Berthold Langguth, MD, PhD4
Author Affiliations
JAMA Otolaryngol Head Neck Surg. Published online September 24, 2020. doi:10.1001/jamaoto.2020.2919
https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2770970
Novel Risk Loci in Tinnitus and Causal Inference With Neuropsychiatric Disorders Among Adults of European Ancestry
The new study identifies candidate genes that could reveal the underlying causes and molecular mechanisms involved in tinnitus and ultimately lead to new targeted treatments.
“Our study has identified a number of interesting candidate genes for further investigation, most notably RCOR1,” write the study authors.
The preprint, which was posted to medRxiv on September 13, 2020, has not yet been certified by peer review but it was supported by funding from some big names such as Action on Hearing Loss and NIHR UCLH BRC (Deafness and Hearing Problems).
Researchers performed a genome-wide association study of tinnitus involving 172,608 volunteers.
Identification of the genetic variants involved in tinnitus would help reveal the nature of the mechanisms involved in generating tinnitus after hearing loss, a requisite for development of treatments. Previous pilot genome-wide association studies and candidate gene studies for tinnitus have lacked sufficient power to establish specific genetic risk factors but the relatively high heritability demonstrates there is potential to use such approaches to reveal the underlying mechanisms.
“Three variants in close proximity to the RCOR1 gene reached genome wide significance,” according to the study.
Worth a read.
Link to study abstract:
https://doi.org/10.1101/2020.09.11.20192583
Link to full text [PDF]:
https://www.medrxiv.org/content/10.1101/2020.09.11.20192583v1.full.pdf
The authors responsible for this fascinating paper (preprint) now at the forefront of the genetics of tinnitus: Helena Rose Rees Wells, Fatin N Zainul Abidin, Maxim Freydin, Frances MK Williams, Sally J Dawson.
It is therefore possible that the association of MYO3B, ARID5B and ZNF318 with tinnitus is secondary to their role in hearing since tinnitus is usually manifested when there is a hearing loss present. However, it may be that the nature of the hearing loss caused by these genes variants creates a deficit which particularly potentiates the generation of tinnitus.
More “tinnitus gene” coverage to follow. How to follow this research? Keep checking the front page or subscribe to email updates and get a once-weekly summary (list) of new links that were recently added.
https://www.medrxiv.org/content/medrxiv/early/2020/09/13/2020.09.11.20192583.full.pdf
Genetic variation in RCOR1 is associated with tinnitus in UK Biobank
Helena Rose Rees Wells, Fatin N Zainul Abidin, Maxim Freydin, Frances MK Williams, Sally J Dawson
doi: https://doi.org/10.1101/2020.09.11.20192583
This article is a preprint and has not been certified by peer review [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.